The JAX NSC has a strong history in providing diverse animal resources to enhance research in the genetics of aging. These resources include >30 common inbred strains for which the JAX NSC freely provided lifespan and comprehensive healthspan data via the interactive Mouse Phenome Database, substantially increasing the value of these common laboratory strains in aging research; large-scale two- and four-way crosses to identify quantitative trait loci (QTL) regulating lifespan and multiple healthspan parameters; and Diversity Outbred (DO) mice, a high resolution genetic mapping population developed by JAX NSC PI Dr. Gary Churchill that promises to finally efficiently bridge the gap between QTL detection and identification of the underlying, causative quantitative trait gene. In the previous funding period, the JAX NSC included two cores, the Animal Core and the Healthspan Core. Both were highly successful and were utilized by many investigators. However, these cores are so closely intertwined by their very nature that we have now combined them into one core, The ?Animal and Phenotyping? Core.
The Specific Aims of the Animal and Phenotyping Core are to:
Aim 1. Develop unique animal resources to support aging research.
Aim 2. Enable characterization of these animal resources by providing robust and novel phenotyping assays relevant to human lifespan and healthspan as well as relevant tissue samples.
Aim 3. Coordinate with the Translational Core to obtain knockout (KO) models for lifespan studies.
Aim 4. Coordinate with the Data and Statistical Core to analyze data and streamline dissemination efforts to the aging community.
| Thompson, Michael J; Chwia?kowska, Karolina; Rubbi, Liudmilla et al. (2018) A multi-tissue full lifespan epigenetic clock for mice. Aging (Albany NY) 10:2832-2854 |
| Backer, Grant; Eddy, Sean; Sheehan, Susan M et al. (2018) FAR2 is associated with kidney disease in mice and humans. Physiol Genomics 50:543-552 |
| Sutphin, George L; Backer, Grant; Sheehan, Susan et al. (2017) Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity. Aging Cell 16:672-682 |
| Lee, Benjamin P; Buri?, Ivana; George-Pandeth, Anupriya et al. (2017) MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep 7:44620 |
| Sutphin, George L; Mahoney, J Matthew; Sheppard, Keith et al. (2016) WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning. PLoS Comput Biol 12:e1005182 |
| Korstanje, Ron; Deutsch, Konstantin; Bolanos-Palmieri, Patricia et al. (2016) Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria. J Am Soc Nephrol 27:3271-3277 |
| Bogue, Molly A; Peters, Luanne L; Paigen, Beverly et al. (2016) Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span. J Gerontol A Biol Sci Med Sci 71:170-7 |
| Didion, John P; Morgan, Andrew P; Yadgary, Liran et al. (2016) R2d2 Drives Selfish Sweeps in the House Mouse. Mol Biol Evol 33:1381-95 |
| Young, Kira; Borikar, Sneha; Bell, Rebecca et al. (2016) Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging. J Exp Med 213:2259-2267 |
| Schoenrock, Sarah Adams; Oreper, Daniel; Young, Nancy et al. (2016) Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice. Physiol Behav 167:404-412 |
Showing the most recent 10 out of 48 publications
