The central premise of the proposed San Antonio Claude D. Pepper Older Americans Independence Center (OAIC) is that basic aging research has advanced to the point where scientifically validated, aging-modulating approaches are ready to be tested and translated into human therapies. We propose an Intervention Program that will advance discoveries obtained in rodents into the pre-clinical arena using a non-human primate model, the common marmoset, and from the pre-clinical arena into humans through clinical studies. Our Center will provide investigators with the scientific infrastructure and services that are requisite to translate innovative interventions that target the aging process and age-related diseases into humans. Initially, our major focus will be on pharmacological interventions, however, regenerative and gene transfer interventions also will be tested as they become available. The Specific Objectives of the OAIC are: 1. To provide, through Resource Core (RC-1), functional assessment (health span) services, and determine the effect of interventions on lifespan. This Core also will support pharmacokinetic, pharmacodynamics, safety, and tolerability assessment of aging-modulating interventions. 2. To provide human clinical research and pharmacology services to studies of interventions aimed at preventing physiological decline and age-related diseases through Resource Core (RC-2). Services provided by this core will include study design, subject recruitment, subject retention, and procedures to assess physical performance, cognition, glucose metabolism, vascular function, atherosclerosis, exercise tolerance, gait, balance, imaging, and specimen (blood, muscle, fat) processing. This core will also perform pharmacokinetic studies in humans. 3. To provide, through the Biostatistics Core (RC3), expertise in data entry systems, data quality control, data security, and state-of-the-art quantitative and qualitative analytic and medical informatics strategies. 4. To provide assistance to faculty for developing research programs in gerontology and geriatrics. The Research Career Development Core (RCDC) will provide protected research time, research training, and mentorship to OAIC Scholars, while the Pilot and Exploratory Studies Core (PESC) will fund pilot projects to gather preliminary data that may guide the design of future studies. All scholars will have research projects, mentoring teams and specific short and long-term career goals.

Public Health Relevance

The aging process plays an important role in the development of chronic disease and contributes to disability and the loss of independence. We propose a program that will develop and test interventions (such as drugs) that may promote healthy aging. This will help to maintain health and independence in older adults.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG044271-03
Application #
9277330
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Eldadah, Basil A
Project Start
2015-06-15
Project End
2020-04-30
Budget Start
2017-07-04
Budget End
2018-04-30
Support Year
3
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Texas Health Science Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Salmon, Adam B; Dorigatti, Jonathan; Huber, Hillary F et al. (2018) Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions. Geroscience 40:269-278
Gelfond, Jonathan; Goros, Martin; Hernandez, Brian et al. (2018) A System for an Accountable Data Analysis Process in R. R J 10:6-21
Sills, Aubrey M; Artavia, Joselyn M; DeRosa, Brian D et al. (2018) Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Am J Primatol :e22927
Noël, Polly Hitchcock; Wang, Chen-Pin; Finley, Erin P et al. (2018) Provider-Related Linkages Between Primary Care Clinics and Community-Based Senior Centers Associated With Diabetes-Related Outcomes. J Appl Gerontol :733464818782853
Reveles, Kelly R; Mortensen, Eric M; Koeller, Jim M et al. (2018) Derivation and Validation of a Clostridium difficile Infection Recurrence Prediction Rule in a National Cohort of Veterans. Pharmacotherapy 38:349-356
Lee, Hak Joo; Feliers, Denis; Barnes, Jeffrey L et al. (2018) Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience 40:163-176
Arora, Sukeshi Patel; Mahalingam, Devalingam (2018) Immunotherapy in colorectal cancer: for the select few or all? J Gastrointest Oncol 9:170-179
Kraig, Ellen; Linehan, Leslie A; Liang, Hanyu et al. (2018) A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects. Exp Gerontol 105:53-69
Ipson, B R; Fletcher, M B; Espinoza, S E et al. (2018) Identifying Exosome-Derived MicroRNAs as Candidate Biomarkers of Frailty. J Frailty Aging 7:100-103
Weiss, Roxanne; Fernandez, Elizabeth; Liu, Yuhong et al. (2018) Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice. Aging (Albany NY) :

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