Late-life disability, defined as needing help with daily activities, is common, burdensome, and costly to patients, families, and society. Late-life disability is influenced by medical vulnerabilities (including comorbid illnesses, aspects of medical care, medicines, procedures, neuropsychiatric conditions, and behaviors), social vulnerabilities (social supports, financial resources, communication and literacy, and ethnicity), and their interaction. The UCSF OAIC will focus its efforts on addressing predictors, characteristics, and outcomes of late-life disability in these vulnerable populations at increased risk for disability or death. The overriding goal of the UCSF OAIC will be to improve the health care and quality of life of vulnerable older adults with or at risk for disability through the follwing aims: 1) Catalyze research on disability in vulnerable older persons at UCSF by serving as a hub that brings together scholars and leverages resources;2) Provide tangible, high-value support to funded projects at UCSF that stimulate new research on disability, and lead to new research opportunities for senior and junior investigators;3) Support pilot studies that accelerat science and lead to research funding in late life disability;4) Identify the future leaders of geriatrics research and support them with career development funding and exceptional mentoring;and 5) Develop a leadership and administrative structure that spurs interdisciplinary collaboration, making the OAIC greater than the sum of its parts. To achieve its aims, the UCSF OAIC will support 5 Cores under the leadership of PI Ken Covinsky. The LAC will provide leadership support for the entire UCSF OAIC. The RCDC will utilize the RCDC Scholars and Advanced Scholars Programs to identify, support, and nurture junior investigators who will become national leaders in aging research. The RDAC will enhance analyses of extramurally funded grants (External Projects), OAIC pilot projects, and RCDC projects, and will conduct a Development Project (DP). The DMAC will help investigators design studies with data sources ideal for disability research, support investigators adding disability measures to ongoing studies, and conduct a DP. The PESC will promote innovative and promising research that enhances our understanding in ways that can mitigate late-life disability, and that leads to ROI funding. By evaluating how medical and social vulnerabilities contribute to the disablement process, the UCSF OAIC will make a meaningful contribution to our understanding of how to best care for older adults who are at risk for or developing disability, advance research and guide clinical practice.

Public Health Relevance

The UCSF OAIC will advance novel concepts, treatments, services, and, ultimately, preventive and therapeutic interventions for socially and medically vulnerable older adults at risk for or developing disability.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG044281-02
Application #
8695263
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Program Officer
Eldadah, Basil A
Project Start
2013-07-15
Project End
2018-06-30
Budget Start
2014-08-15
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$1,083,654
Indirect Cost
$397,797
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Greene, Meredith; Ahalt, Cyrus; Stijacic-Cenzer, Irena et al. (2018) Older adults in jail: high rates and early onset of geriatric conditions. Health Justice 6:3
Hunt, Lauren J; Lee, See J; Harrison, Krista L et al. (2018) Secondary Analysis of Existing Datasets for Dementia and Palliative Care Research: High-Value Applications and Key Considerations. J Palliat Med 21:130-142
Lai, Jennifer C; Segev, Dorry L; McCulloch, Charles E et al. (2018) Physical frailty after liver transplantation. Am J Transplant 18:1986-1994
Bischoff, Kara; O'Riordan, David L; Marks, Angela K et al. (2018) Care Planning for Inpatients Referred for Palliative Care Consultation. JAMA Intern Med 178:48-54
Humphreys, Jessi; Ahalt, Cyrus; Stijacic-Cenzer, Irena et al. (2018) Six-Month Emergency Department Use among Older Adults Following Jail Incarceration. J Urban Health 95:523-533
Kata, Anna; Sudore, Rebecca; Finlayson, Emily et al. (2018) Increasing Advance Care Planning Using a Surgical Optimization Program for Older Adults. J Am Geriatr Soc 66:2017-2021
Walker, Evan; McMahan, Ryan; Barnes, Deborah et al. (2018) Advance Care Planning Documentation Practices and Accessibility in the Electronic Health Record: Implications for Patient Safety. J Pain Symptom Manage 55:256-264
Ishida, Julie H; McCulloch, Charles E; Steinman, Michael A et al. (2018) Opioid Analgesics and Adverse Outcomes among Hemodialysis Patients. Clin J Am Soc Nephrol 13:746-753
Wehner, M R; Dalma, N; Landefeld, C et al. (2018) Natural history of lesions suspicious for basal cell carcinoma in older adults in Ikaria, Greece. Br J Dermatol 179:767-768
Shi, Ying; Fung, Kathy Z; John Boscardin, W et al. (2018) Individualizing PSA Monitoring Among Older Prostate Cancer Survivors. J Gen Intern Med 33:602-604

Showing the most recent 10 out of 234 publications