The proposed Neuroimaging Core (NIC) of the newly established Wake Forest Alzheimer?s Disease Core Center (ADCC) will provide biennial magnetic resonance imaging (MRI), amyloid positron emission tomography (11C-PiB PET) and tau PET (18F-AV-1451) to 200 ethnically diverse Clinical Core participants (100 normal older adults and 100 adults with mild cognitive impairment/MCI; 1/3 of each from underrepresented groups) using state of the art protocols optimized for sharing with the National Alzheimer?s Coordinating Center (NACC) and with other investigators. In addition, innovative specialized sequences to assess vascular integrity will be conducted, including multiphase pseudocontinuous arterial spin label (ASL) MRI, and controlled measures of hypercapnic cerebrovascular reactivity (CVR). Thus, the new NIC will enable Wake Forest to provide specialized resources to conduct high impact research examining the longitudinal interaction of AD and vascular pathologies in an ethnically diverse, deeply phenotyped cohort. To facilitate translational research, the NIC will also apply AD MRI protocols to non-human primates (NHP) who spontaneously develop age-related amyloid pathology and metabolic/vascular disease. The Core will leverage an extensive imaging infrastructure with dedicated research resources, including a 3T Siemens Skyra MRI scanner with a high-resolution 32- channel head coil, GE 16-slice PET/CT Discovery ST Scanner, GE PETtrace 10 Cyclotron Radiotracer Production System, and automated analytic pipelines. NIC members will also carry out educational and consultation activities to encourage the expansion of AD-related imaging research at Wake Forest. Led by neuroradiologist Christopher Whitlow, MD, PhD, Director of the Translational Imaging Program of the Clinical and Translational Science Institute (CTSI), and Sam Lockhart, PhD, a neuroimaging investigator with extensive published experience in MR and PET imaging related to AD, vascular pathology, and cognition, the NIC will: 1) conduct state of the art longitudinal MR, amyloid, and tau imaging in Wake Forest ADCC?s ethnically diverse Clinical Core, using protocols aligned with the national ADC network; 2) refine and implement sensitive MRI protocols for vascular integrity (ASL and CVR) that will facilitate understanding of the relationships between vascular and AD pathology and provide methodological innovations to enhance the reliability of multi-site vascular imaging; 3) develop and implement neuroimaging protocols for innovative translational NHP models; and 4) integrate quality-controlled imaging data with clinical and other biomarker data in a user-friendly relational database to facilitate dissemination and use by ADCC, NACC and other investigators.
This application proposes the addition of a new Neuroimaging Core to the Wake Forest Alzheimer?s Disease Core Center (ADCC). Establishment of this Neuroimaging Core will enable long-term, repeated observation of the pathological changes associated with cognitive decline in Alzheimer?s disease using multiple neuroimaging techniques in well-characterized study participants. The Neuroimaging Core will help Wake Forest ADCC researchers differentiate AD from other dementias and address important scientific questions, such as the contributions of vascular and metabolic risk factors in multiple ethnic groups, and will greatly expand the resources that are provided by the ADCC to the broader Alzheimer?s disease research field. !
|Crum, Jana; Wilson, Jeffrey; Sabbagh, Marwan (2018) Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia? Alzheimers Res Ther 10:104|
|Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826|
|Kaur, Antarpreet; Edland, Steven D; Peavy, Guerry M (2018) The MoCA-Memory Index Score: An Efficient Alternative to Paragraph Recall for the Detection of Amnestic Mild Cognitive Impairment. Alzheimer Dis Assoc Disord 32:120-124|
|Brenowitz, Willa D; Han, Fang; Kukull, Walter A et al. (2018) Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging 62:64-71|
|Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:|
|Espeland, Mark A; Carmichael, Owen; Yasar, Sevil et al. (2018) Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes. Alzheimers Dement 14:1184-1192|
|Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642|
|Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827|
|Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064|
|Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10|
Showing the most recent 10 out of 34 publications