Abstract

The MOLECULAR VIROLOGY CORE in this CFAR proposal will provide equipment, materials, and expertise for supporting research projects that require molecular cloning, radioactive and non- radioactive probes, synthetic oligonucleotides, expression vector systems, DNA sequencing, and analysis of viral and cellular macromolecules (polypeptides, RNA, and DNA). These projects involve several retroviruses including human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2), simian immunodeficiency viruses (SIV) from rhesus macaque and sooty mangabey monkeys, feline T-lymphotropic virus (FTLV), simian AIDS-associated retrovirus (SRV, a type D retrovirus), bovine immunodeficiency-like virus (BIV), visna virus, and caprine-arthritis-encephalitis virus (CAEV) as well as several DNA viruses (e.g., rhesus and human cytomegaloviruses, rhesus Epstein-Barr virus, rhesus denovirus, vaccina virus). These activities in the MOLECULAR VIROLOGY CORE involve many direct interactions with investigators in both the PRIMATE CENTER and the CLINICAL VIROLOGY CORES.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
1P30AI027732-01
Application #
3818948
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Yamanaka, M K; Yilma, T (1998) Altered plaque formation by recombinant vaccinia virus expressing simian immunodeficiency virus Nef. J Virol 72:5291-5
Giavedoni, L D; Yilma, T (1996) Construction and characterization of replication-competent simian immunodeficiency virus vectors that express gamma interferon. J Virol 70:2247-51
Gardner, M; Rosenthal, A; Jennings, M et al. (1995) Passive immunization of rhesus macaques against SIV infection and disease. AIDS Res Hum Retroviruses 11:843-54
Luciw, P A; Pratt-Lowe, E; Shaw, K E et al. (1995) Persistent infection of rhesus macaques with T-cell-line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV). Proc Natl Acad Sci U S A 92:7490-4
Gardner, M B; Rosenthal, A; Jennings, M et al. (1994) Passive immunization of macaques against SIV infection. J Med Primatol 23:164-74
Ahmad, S; Lohman, B; Marthas, M et al. (1994) Reduced virus load in rhesus macaques immunized with recombinant gp160 and challenged with simian immunodeficiency virus. AIDS Res Hum Retroviruses 10:195-204
Herchenroder, O; Renne, R; Loncar, D et al. (1994) Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz): high homology to human foamy virus (HFV). Virology 201:187-99
Anderson, D E; Malley, A; Benjamini, E et al. (1994) Hypervariable epitope constructs as a means of accounting for epitope variability. Vaccine 12:736-40
Torres, J V; Anderson, D E; Malley, A et al. (1993) SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques. J Med Primatol 22:129-37
Giavedoni, L D; Planelles, V; Haigwood, N L et al. (1993) Immune response of rhesus macaques to recombinant simian immunodeficiency virus gp130 does not protect from challenge infection. J Virol 67:577-83

Showing the most recent 10 out of 25 publications