In the four years since the establishment of the NYU CFAR, a great deal has been accomplished. CFAR provided the matrix for the formation of the Aaron Diamond AIDS Research Center (ADARC), which has since grown to a staff of 0 researchers. CFAR has recruited 12 new faculty members engaged in AIDS research, including Dr. David D. Ho, who is the Director of ADARC and the Principal Investigator of our current application. The AIDS research base at NYU has grown substantially to the current level of $5.1 million of annual direct support from the NIAID with additional $5.5 million from other NIH institutes or funding agencies. Our research portfolio includes notable projects such as the adult and pediatric ACTU's, The Ariel Project for the Prevention of HIV Transmission from Mother of Infant, the NIAID Contract on Antigenic Variation of HIV-1, and NCVDG grant, and HIV Vaccine Preparedness Initiative (PAVE) grant. NYU investigators have produced over 500 publications, including 187 peer- reviewed, original papers. Our CFAR has also evolved to better accommodate the growing number of basic scientists doing AIDS interdisciplinary programs directed at important questions at the interface between clinical and basic sciences. HIV Pathogenesis, Transmission, and Vaccine Research have been chosen for emphasis because of their multidisciplinary nature and because our CFAR members are internationally recognized for their contributions in each of these areas. These and other research programs will be supported by newly organized core facilities, including Virology, Flow/cytometry, Immunology, Clinical, SCID Mouse, Primate Model, and Advanced Molecular Technology Cores. The CFAR will continue to provide a proper environment and the necessary resources for AIDS researchers at NYU to work together synergistically to find solutions to end this tragic epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
3P30AI027742-09S1
Application #
2728230
Study Section
Special Emphasis Panel (SRC (71))
Project Start
1989-09-01
Project End
1999-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Gornalusse, German G; Mummidi, Srinivas; Gaitan, Alvaro A et al. (2015) Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Proc Natl Acad Sci U S A 112:E4762-71
Miller, Elizabeth A; Gopal, Ramya; Valdes, Vanessa et al. (2015) Soluble CD40 ligand contributes to dendritic cell-mediated T-cell dysfunction in HIV-1 infection. AIDS 29:1287-96
Weiden, Michael D; Hoshino, Satomi; Levy, David N et al. (2014) Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages. PLoS One 9:e108476
Ryndak, Michelle B; Singh, Krishna K; Peng, Zhengyu et al. (2014) Transcriptional profiling of Mycobacterium tuberculosis replicating ex vivo in blood from HIV- and HIV+ subjects. PLoS One 9:e94939
Phelan, Joan A; Abrams, William R; Norman, Robert G et al. (2014) Design aspects of a case-control clinical investigation of the effect of HIV on oral and gastrointestinal soluble innate factors and microbes. PLoS One 9:e112901
Sivapalasingam, Sumathi; Mendillo, Megan; Ahmed, Aabid et al. (2014) The importance of caregivers in the outcome of pediatric HIV management, Mombasa, Kenya. AIDS Care 26:425-33
Rich, Josiah D; DiClemente, Ralph; Levy, Judith et al. (2013) Correctional facilities as partners in reducing HIV disparities. J Acquir Immune Defic Syndr 63 Suppl 1:S49-53
Weiser, Keren; Barton, Meredith; Gershoony, Dafna et al. (2013) HIV's Nef interacts with ?-catenin of the Wnt signaling pathway in HEK293 cells. PLoS One 8:e77865
O'Brien, Meagan; Montenont, Emilie; Hu, Liang et al. (2013) Aspirin attenuates platelet activation and immune activation in HIV-1-infected subjects on antiretroviral therapy: a pilot study. J Acquir Immune Defic Syndr 63:280-8
Alvarez, Yelina; Tuen, Michael; NĂ das, Arthur et al. (2012) In vitro restoration of Th17 response during HIV infection with an antiretroviral drug and Th17 differentiation cytokines. AIDS Res Hum Retroviruses 28:823-34

Showing the most recent 10 out of 254 publications