Clinical Retrovirology

Coombs, Robert W.

Abstract

CORE F - University of Washington CFAR Clinical Retrovirology Laboratory Core. Director-Robert W Coombs, M.D., Ph.D., Professor, Departments of Laboratory Medicine &Medicine;Co-Director, Tuofu Zhu, M.D., Ph.D., Associate Professor, Department of Laboratory Medicine. SPECIFIC PURPOSE AND KEY SCIENTIFIC PROJECTS SUPPORTED. The specific purpose of the Clinical Retrovirology Laboratory Core is to facilitate the translational and interdisciplinary CFAR research agenda of prevention, pathogenesis and treatment of HIV infection by providing and developing HIV virology laboratory support and services for CFAR investigators. This purpose will be accomplished by providing virological markers of disease progression and regression and maintenance of a CFAR specimen repository in conjunction with the Clinical Research Core. In addition, to serological diagnosis of HIV, viral isolation, RNA and DMA quantification, and detection procedures for HIV shedding from mucosal surfaces are also available and a special expertise of Core F. A diverse virological laboratory base is important for elucidating HIV pathogenesis, vaccines and treatment strategies, which are major themes of the UW CFAR proposal. The key scientific projects in progress and currently supported by the Clinical Retrovirology Core Laboratory include: Continued laboratory support of the Adult and Pediatric AIDS Clinical Trials Networks (AI-27664;Al- 32910), HIV Vaccine Trials Network (AI-26503) and Primary Infection Program (AI-57005);HIV-1 shedding, transmission and tropism (AI-38518;R21 pending);Evolution of HIV-1 variants in semen and blood (Al- 32885, AI-35539);Virological and host determinants of HIV-1 shedding in semen (DK-49477);Effect of female genital tract infection on HIV-1 shedding and evolution (HD40540);Effect of mucosal inflammation and HSV on HIV shedding (AI-4798;CFAR/CIPRA programs);Lymphoctye adhesion and HIV activation in the lung (RO1-HL083481);Mycobacterium infection and host defense (K08-HL03577);Pathogenesis of HIV env and vaccines (AI-47086;AI-065328;HD-38653);and HIV CNS infection and dementia (R21-MH63647).

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Center Core Grants (P30)
• Project #: 5P30AI027757-23
• Application #: 8080966
• Study Section: Special Emphasis Panel (ZAI1)
• Budget Start: 2010-06-01
• Budget End: 2011-05-31
• Support Year: 23
• Fiscal Year: 2010
• Total Cost: $173,654

Institution

• Name: University of Washington
• DUNS #: 605799469
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98195

Publications

Young, J; Smith, C; Teira, R et al. (2018) Antiretroviral pill count and clinical outcomes in treatment-naïve patients with HIV infection. HIV Med 19:132-142

Olwit, Connie; Mugaba, Maureen; Osingada, Charles Peter et al. (2018) Existence, triggers, and coping with chronic sorrow: a qualitative study of caretakers of children with sickle cell disease in a National Referral Hospital in Kampala, Uganda. BMC Psychol 6:50

Torres, Thiago S; Harrison, Linda J; La Rosa, Alberto M et al. (2018) Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings. AIDS Care 30:954-962

Heffron, Renee; Mugo, Nelly; Hong, Ting et al. (2018) Pregnancy outcomes and infant growth among babies with in-utero exposure to tenofovir-based preexposure prophylaxis for HIV prevention. AIDS 32:1707-1713

Pyra, Maria; Brown, Elizabeth R; Haberer, Jessica E et al. (2018) Patterns of Oral PrEP Adherence and HIV Risk Among Eastern African Women in HIV Serodiscordant Partnerships. AIDS Behav :

Jiang, Wei; Luo, Zhenwu; Martin, Lisa et al. (2018) Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy. Curr HIV Res 16:143-150

Edwards, Jessie K; Cole, Stephen R; Moore, Richard D et al. (2018) Sensitivity Analyses for Misclassification of Cause of Death in the Parametric G-Formula. Am J Epidemiol :

LaCourse, Sylvia M; Cranmer, Lisa M; Bekker, Adrie et al. (2018) Symptom screening for active tuberculosis in pregnant women living with HIV. Cochrane Database Syst Rev 2018:

Merlin, Jessica S; Long, Dustin; Becker, William C et al. (2018) Brief Report: The Association of Chronic Pain and Long-Term Opioid Therapy With HIV Treatment Outcomes. J Acquir Immune Defic Syndr 79:77-82

Wagner, Anjuli D; O?Malley, Gabrielle; Firdawsi, Olivia et al. (2018) Brief Report: Disclosure, Consent, Opportunity Costs, and Inaccurate Risk Assessment Deter Pediatric HIV Testing: A Mixed-Methods Study. J Acquir Immune Defic Syndr 77:393-399