The mission of the UCSF-Gladstone Center for AIDS Research (CFAR) is to promote multidisciplinary research at the intersection of the basic, clinical, and behavioral-epidemiological sciences with the goal of ending the global HIV epidemic. To fulfill its mission, CFAR collaborates with UCSF's AIDS Research Institute and the Center for AIDS Prevention Studies (CAPS), as well as the newly funded amfAR Institute for HIV Cure Research, to coordinate a multi-pronged program that aims to: 1) Provide administrative and scientific leadership through a proactive planning process that identifies the most important challenges emerging at the cutting edge of HIV research 2) Identify, mentor, and support a highly skilled, diverse, and thoughtful next generation of HIV investigators by providing a strong mentoring program unique to UCSF and through a California-funded Health Disparities Core linked to CFAR 3) Conduct a dynamic pilot grants program to accelerate discovery 4) Maintain an outstanding set of scientific cores to extend the reach of Center investigators' research 5) Ensure our programs support major NIH-funded HIV/AIDS research programs and OAR priorities 6) Confront domestic prevention and treatment disparities through effective local collaborations 7) Direct CFAR's research and capacity building programs to international sites where the epidemic is hitting the hardest 8) Engage the communities we serve through a set of novel alliances involving Project Inform, the Forum for Collaborative HIV Research, and UCSF's Science and Health Education Partnership 9) Forge effective inter-CFAR collaborations to nucleate research teams across different disciplines and sites to address all dimensions of these identified challenges CFAR brings value by creating and sustaining a true community of HIV/AIDS science. CFAR is proud of its accomplishments in the last four years including: the publication of 791 papers; the mentoring of 69 early career investigators; the award of $6.1 million to support 79 CFAR grants and supplements; the success of recent CFAR awardees in winning more than $106.7 million dollars in peer-reviewed, HIV-related funding; and our continuing engagement in the planning and organization of the East Africa Collaborative Scientific Symposium and Sub-Saharan Africa CFAR Conferences featuring the work of African scientists. However, much work remains to be done. CFAR looks forward to helping stimulate progress on multiple scientific fronts including increasing access to implementation science methods, driving progress in HIV eradication, increasing access to proven biomedical approaches to HIV prevention and addressing disparities in HIV care and treatment within resource-limited communities in the Bay Area and abroad.

Public Health Relevance

The mission of the UCSF-Gladstone Center for AIDS Research (CFAR) is to promote multidisciplinary research at the intersection of the basic, clinical, and behavioral-epidemiological sciences with the goal of ending the global HIV epidemic. To fulfill its mission, CFAR collaborates with UCSF's AIDS Research Institute and the Center for AIDS Prevention Studies (CAPS), as well as the newly funded amfAR Institute for HIV Cure Research, to coordinate a multi-pronged program that aims to: Provide administrative and scientific leadership through a proactive planning process that identifies the most important challenges emerging at the cutting edge of HIV research; Identify, mentor, and support a highly skilled, diverse, and thoughtful next generation of HIV investigators by providing a strong mentoring program unique to UCSF and through a California-funded Health Disparities Core linked to CFAR; Conduct a dynamic pilot grants program to accelerate discovery; Maintain an outstanding set of scientific cores to extend the reach of Center investigators' research; Ensure our programs support major NIH-funded HIV/AIDS research programs and OAR priorities; Confront domestic prevention and treatment disparities through effective local collaborations; Direct CFAR's research and capacity building programs to international sites where the epidemic is hitting the hardest Engage the communities we serve through a set of novel alliances involving Project Inform, the Forum for Collaborative HIV Research, and UCSF's Science and Health Education Partnership; and Forge effective inter-CFAR collaborations to nucleate research teams across different disciplines and sites to address all dimensions of these identified challenges. CFAR brings value by creating and sustaining a true community of HIV/AIDS science. CFAR is proud of its accomplishments in the last four years including: the publication of 791 papers; the mentoring of 69 early career investigators; the award of $6.1 million to support 79 CFAR grants and supplements; the success of recent CFAR awardees in winning more than $106.7 million dollars in peer- reviewed, HIV-related funding; and our continued engagement in East Africa. CFAR will to helping stimulate progress on multiple scientific fronts including increasing access to implementation science methods, driving progress in HIV eradication, increasing access to proven biomedical approaches to HIV prevention and addressing disparities in HIV care and treatment within resource-limited communities in the Bay Area and abroad.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027763-29
Application #
9998831
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Refsland, Eric William
Project Start
1997-03-01
Project End
2022-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
29
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Pulugulla, Sree H; Packard, Thomas A; Galloway, Nicole L K et al. (2018) Distinct mechanisms regulate IL1B gene transcription in lymphoid CD4 T cells and monocytes. Cytokine 111:373-381
Mohamed, Tamer M A; Ang, Yen-Sin; Radzinsky, Ethan et al. (2018) Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Cell 173:104-116.e12
Chammartin, Frédérique; Zürcher, Kathrin; Keiser, Olivia et al. (2018) Outcomes of Patients Lost to Follow-up in African Antiretroviral Therapy Programs: Individual Patient Data Meta-analysis. Clin Infect Dis 67:1643-1652
Vardi, Noam; Chaturvedi, Sonali; Weinberger, Leor S (2018) Feedback-mediated signal conversion promotes viral fitness. Proc Natl Acad Sci U S A 115:E8803-E8810
Carrico, Adam W; Flentje, Annesa; Kober, Kord et al. (2018) Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection. Brain Behav Immun 71:108-115
Bengtson, Angela M; Pence, Brian W; Eaton, Ellen F et al. (2018) Patterns of efavirenz use as first-line antiretroviral therapy in the United States: 1999-2015. Antivir Ther 23:363-372
Sauceda, John A; Lisha, Nadra E; Neilands, Torsten B et al. (2018) Cognitive-affective depressive symptoms and substance use among Latino and non-Latino White patients in HIV care: an analysis of the CFAR network of integrated clinical systems cohort. J Behav Med :
Carrico, Adam W; Cherenack, Emily M; Roach, Margaret E et al. (2018) Substance-associated elevations in monocyte activation among methamphetamine users with treated HIV infection. AIDS 32:767-771
Tymejczyk, Olga; Brazier, Ellen; Yiannoutsos, Constantin et al. (2018) HIV treatment eligibility expansion and timely antiretroviral treatment initiation following enrollment in HIV care: A metaregression analysis of programmatic data from 22 countries. PLoS Med 15:e1002534
Martin, Maureen P; Naranbhai, Vivek; Shea, Patrick R et al. (2018) Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest 128:1903-1912

Showing the most recent 10 out of 1541 publications