The DNA Sequence and Analysis Core has been in operation for the past five years and has provided CFAR members with state-of-the-art automated sequencing and computer analysis capabilities. Major goals of the Sequence and Analysis Core have been: (i) to provide automated DNA sequencing capabilities to AIDS Center members through the availability and maintenance of an Applied Biosystems DNA Sequencer; (ii) to provide technical support and training in cycle sequencing methodologies utilizing both dye primer and dye terminator approaches; (iii) to maintain and update a comprehensive set of nucleic acids and protein sequence analysis programs from the Wisconsin Genetics Computer Group; (iv) to provide technical support and training in the use of these nucleic acid and protein sequence analysis programs. Providing these service, the Sequencing Core has supported over 50 funded grants and contracts of 38 CFAR members and has been instrumental for the preparation of over 180 manuscripts. Moreover, the automated DNA sequenator is an integral part of several currently funded research projects and is estimated to generate over 500,000 bp of raw sequence data in the next year. Finally, the sequence analysis and training aspect of the Sequencing Core is used by virtually all CFAR members who have a molecular biology program. Support for this resource which currently operates at a 50% charge-back level is thus instrumental for the continuing success of several HIV pathogenesis, vaccine, and drug studies currently conducted at UAB.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027767-06
Application #
3747016
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Smith, Samuel R; Schaaf, Kaitlyn; Rajabalee, Nusrah et al. (2018) The phosphatase PPM1A controls monocyte-to-macrophage differentiation. Sci Rep 8:902
Wang, Yong; Schafer, Cara C; Hough, Kenneth P et al. (2018) Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5. J Immunol 201:278-295
Jones, Robert B; Dorsett, Kaitlyn A; Hjelmeland, Anita B et al. (2018) The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1? signaling. J Biol Chem 293:5659-5667
Frugé, Andrew D; Van der Pol, William; Rogers, Laura Q et al. (2018) Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial. J Acad Nutr Diet :
Dionne-Odom, Jodie; Westfall, Andrew O; Van Der Pol, Barbara et al. (2018) Sexually Transmitted Infection Prevalence in Women With HIV: Is There a Role for Targeted Screening? Sex Transm Dis 45:762-769
Crenshaw, Brennetta J; Gu, Linlin; Sims, Brian et al. (2018) Exosome Biogenesis and Biological Function in Response to Viral Infections. Open Virol J 12:134-148
Howe, Chanelle J; Dulin-Keita, Akilah; Cole, Stephen R et al. (2018) Evaluating the Population Impact on Racial/Ethnic Disparities in HIV in Adulthood of Intervening on Specific Targets: A Conceptual and Methodological Framework. Am J Epidemiol 187:316-325
Sahay, Bikash; Bashant, Kathleen; Nelson, Nicole L J et al. (2018) Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling. Infect Immun 86:
Trapecar, Martin; Khan, Shahzada; Cohn, Benjamin L et al. (2018) B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection. Mucosal Immunol 11:1158-1167
Verma, Richa; Sahu, Rajnish; Dixit, Saurabh et al. (2018) The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic Front Immunol 9:2369

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