The DNA Sequence and Analysis Core has been in operation for the past five years and has provided CFAR members with state-of-the-art automated sequencing and computer analysis capabilities. Major goals of the Sequence and Analysis Core have been: (i) to provide automated DNA sequencing capabilities to AIDS Center members through the availability and maintenance of an Applied Biosystems DNA Sequencer; (ii) to provide technical support and training in cycle sequencing methodologies utilizing both dye primer and dye terminator approaches; (iii) to maintain and update a comprehensive set of nucleic acids and protein sequence analysis programs from the Wisconsin Genetics Computer Group; (iv) to provide technical support and training in the use of these nucleic acid and protein sequence analysis programs. Providing these service, the Sequencing Core has supported over 50 funded grants and contracts of 38 CFAR members and has been instrumental for the preparation of over 180 manuscripts. Moreover, the automated DNA sequenator is an integral part of several currently funded research projects and is estimated to generate over 500,000 bp of raw sequence data in the next year. Finally, the sequence analysis and training aspect of the Sequencing Core is used by virtually all CFAR members who have a molecular biology program. Support for this resource which currently operates at a 50% charge-back level is thus instrumental for the continuing success of several HIV pathogenesis, vaccine, and drug studies currently conducted at UAB.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027767-06
Application #
3747016
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Peng, Binghao J; Carlson, Jonathan M; Liu, Michael K P et al. (2018) Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection. J Virol 92:
Shi, Bi; Geng, Jianlin; Wang, Yin-Hu et al. (2018) Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4. J Immunol 200:586-594
Moshiri, Niema; Mirarab, Siavash (2018) A Two-State Model of Tree Evolution and Its Applications to Alu Retrotransposition. Syst Biol 67:475-489
Crockett, Kaylee B; Rice, Whitney S; Turan, Bulent (2018) Associations Between Multiple Forms of Discrimination and Tobacco Use Among People Living With HIV: The Mediating Role of Avoidance Coping. J Acquir Immune Defic Syndr 78:9-15
Mai, Uyen; Mirarab, Siavash (2018) TreeShrink: fast and accurate detection of outlier long branches in collections of phylogenetic trees. BMC Genomics 19:272
Tomalka, Amanda G; Resto-Garay, Ivelisse; Campbell, Kerry S et al. (2018) In vitro Evidence That Combination Therapy With CD16-Bearing NK-92 Cells and FDA-Approved Alefacept Can Selectively Target the Latent HIV Reservoir in CD4+ CD2hi Memory T Cells. Front Immunol 9:2552
Ram, Daniel R; Manickam, Cordelia; Hueber, Brady et al. (2018) Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques. PLoS Pathog 14:e1007104
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Rice, Whitney S; Logie, Carmen H; Napoles, Tessa M et al. (2018) Perceptions of intersectional stigma among diverse women living with HIV in the United States. Soc Sci Med 208:9-17
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72

Showing the most recent 10 out of 955 publications