The DNA Sequence and Analysis Core has been in operation for the past five years and has provided CFAR members with state-of-the-art automated sequencing and computer analysis capabilities. Major goals of the Sequence and Analysis Core have been: (i) to provide automated DNA sequencing capabilities to AIDS Center members through the availability and maintenance of an Applied Biosystems DNA Sequencer; (ii) to provide technical support and training in cycle sequencing methodologies utilizing both dye primer and dye terminator approaches; (iii) to maintain and update a comprehensive set of nucleic acids and protein sequence analysis programs from the Wisconsin Genetics Computer Group; (iv) to provide technical support and training in the use of these nucleic acid and protein sequence analysis programs. Providing these service, the Sequencing Core has supported over 50 funded grants and contracts of 38 CFAR members and has been instrumental for the preparation of over 180 manuscripts. Moreover, the automated DNA sequenator is an integral part of several currently funded research projects and is estimated to generate over 500,000 bp of raw sequence data in the next year. Finally, the sequence analysis and training aspect of the Sequencing Core is used by virtually all CFAR members who have a molecular biology program. Support for this resource which currently operates at a 50% charge-back level is thus instrumental for the continuing success of several HIV pathogenesis, vaccine, and drug studies currently conducted at UAB.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027767-06
Application #
3747016
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Rice, Whitney S; Logie, Carmen H; Napoles, Tessa M et al. (2018) Perceptions of intersectional stigma among diverse women living with HIV in the United States. Soc Sci Med 208:9-17
Stoll, Matthew L; Weiss, Pamela F; Weiss, Jennifer E et al. (2018) Age and fecal microbial strain-specific differences in patients with spondyloarthritis. Arthritis Res Ther 20:14
Fredericksen, R J; Gibbons, L; Brown, S et al. (2018) Medication understanding among patients living with multiple chronic conditions: Implications for patient-reported measures of adherence. Res Social Adm Pharm 14:540-544
Kay, Emma S; Rice, Whitney S; Crockett, Kaylee B et al. (2018) Experienced HIV-Related Stigma in Health Care and Community Settings: Mediated Associations With Psychosocial and Health Outcomes. J Acquir Immune Defic Syndr 77:257-263
Subramaniam, Akila; Van Der Pol, William J; Ptacek, Travis et al. (2018) Midtrimester microbial DNA variations in maternal serum of women who experience spontaneous preterm birth. J Matern Fetal Neonatal Med :1-9
Xu, Wanli; Luo, Zhenwu; Alekseyenko, Alexander V et al. (2018) Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Sci Rep 8:12863
Smith, Samuel R; Schaaf, Kaitlyn; Rajabalee, Nusrah et al. (2018) The phosphatase PPM1A controls monocyte-to-macrophage differentiation. Sci Rep 8:902
Wang, Yong; Schafer, Cara C; Hough, Kenneth P et al. (2018) Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5. J Immunol 201:278-295
Jones, Robert B; Dorsett, Kaitlyn A; Hjelmeland, Anita B et al. (2018) The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1? signaling. J Biol Chem 293:5659-5667

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