The UAB Center for AIDS Research (CFAR) is a designated University-wide Center, a department-level status, and is concerned by a Constitution and By-Laws. The overall research goals of investigators in the UAB CFAR are to understand at the molecular level, and at the level of the infected individual, the pathogenesis of HIV infection and to utilize this information in conjunction with investigators pursuing experimental therapeutics, vaccine development, and behavioral modification to interfere with this pathogenic process. The multidisciplinary base of the Center ensures the rapid translation of fundamental knowledge about AIDS and its related disorders into these clinical treatment and prevention programs. In order to facilitate this process, the major objectives of the Center for AIDS Research are threefold. 1. To enhance ongoing outstanding research programs by facilitating interdisciplinary interactions, providing critical shared resource facilities, and providing administrative and fiscal management support mechanisms for Center investigators. 2. To stimulate participation of existing junior and established faculty in research programs aimed at AIDS-related subjects. This will be through the continued administration of a peer-reviewed competitive Developmental Grant Program that will provide funding for both developmental and pilot grants. 3. To stimulate recruitment and program developmental efforts in AIDS- related areas. The Center has identified new program areas and will assist Departments and Divisions in the process of investigator recruitment. Thus we anticipate continued growth and development of AIDS-related research in the CFAR. The Center will be led Dr. Eric Hunter (Director) and by an Executive Steering Committee consisting of Dr. George Shaw (Deputy Director) and seven Associate Directors, Drs. Beatrice Hahn (Basic Sciences and Program Development), Laura Leviton (Prevention Sciences), Jiri Mestecky (Vaccine Development), Michael Saag (Clinical Care and Experimental Therapeutics), John-Pierre Sommadossi (Pre-Clinical Therapeutics Development), Richard Whitley (Clinical Sciences) and Sten Vermund (Epidemiology). The Center is comprised of 120 Center members from 24 Divisions and Departments within the University funded by more than 100 AIDS-related grants and contracts totalling more than $35 million in research support. Eleven Core Facilities are proposed (Clinical, Biostatistics, Central Virus, Molecular Biology, DNA Sequence, Flow Cytometry, SCID-hu Mouse, International Research, and Behavioral Science, as well as Developmental and Administrative) that will provide key support for this funded research base. From its inception, the UAB CFAR has played a pivotal role in stimulating and supporting basic and clinical AIDS research and linking the two through interdisciplinary research programs. This has been most evident in the Center's principal thematic areas of viral pathogenesis, experimental therapeutics, and vaccine development. The success of the UAB CFAR is reflected in the growth in extramural funding for AIDS-related research from $4.0 million in 1988 (annual costs) to greater than $35.o million in 1997 (annual costs), the increase in number of R01-type AIDS-related grants from 5 to 50 during this same period, and the large number (>1,000) of AIDS-related publications by Center members in peer-reviewed scientific journals between 1993 and 1997. All of the major research efforts within the Center link basic and clinical/behavioral research and together they utilize every shared facility supported by the CFAR Core grant.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027767-11
Application #
2595178
Study Section
Special Emphasis Panel (ZAI1-SCO-A (J1))
Project Start
1988-03-30
Project End
2003-02-28
Budget Start
1998-09-01
Budget End
1999-02-28
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Adeli, Ehsan; Kwon, Dongjin; Zhao, Qingyu et al. (2018) Chained regularization for identifying brain patterns specific to HIV infection. Neuroimage 183:425-437
Verma, Richa; Sahu, Rajnish; Dixit, Saurabh et al. (2018) The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic Front Immunol 9:2369
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Crockett, Kaylee B; Turan, Bulent (2018) Moment-to-moment changes in perceived social support and pain for men living with HIV: an experience sampling study. Pain 159:2503-2511
Carson, Tiffany L; Wang, Fuchenchu; Cui, Xiangqin et al. (2018) Associations Between Race, Perceived Psychological Stress, and the Gut Microbiota in a Sample of Generally Healthy Black and White Women: A Pilot Study on the Role of Race and Perceived Psychological Stress. Psychosom Med 80:640-648
Salantes, D Brenda; Zheng, Yu; Mampe, Felicity et al. (2018) HIV-1 latent reservoir size and diversity are stable following brief treatment interruption. J Clin Invest 128:3102-3115
Goodin, Burel R; Owens, Michael A; White, Dyan M et al. (2018) Intersectional health-related stigma in persons living with HIV and chronic pain: implications for depressive symptoms. AIDS Care 30:66-73
Jiang, Wei; Luo, Zhenwu; Martin, Lisa et al. (2018) Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy. Curr HIV Res 16:143-150
Bilal, Usama; McCaul, Mary E; Crane, Heidi M et al. (2018) Predictors of Longitudinal Trajectories of Alcohol Consumption in People with HIV. Alcohol Clin Exp Res 42:561-570
Bekhbat, Mandakh; Mehta, C Christina; Kelly, Sean D et al. (2018) HIV and symptoms of depression are independently associated with impaired glucocorticoid signaling. Psychoneuroendocrinology 96:118-125

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