Since the inception of the UAB CFAR, the DNA Sequencing Core has provided CFAR members with state of- the-art Sanger DNA sequencing and bioinformatics analytical capabilities. In order for CFAR investigators to meet the challenges of HIV/AIDS research in the treatment era, it was necessary to refine and expand the services provided by the Core. The overall goal of the new CFAR Genomics Core is to provide its investigators access to cutting-edge genomics resources and methodologies designed to facilitate HIV/AIDS related research.
Specific Aims of the Genomic Core are;1. Provide genetic and genomic analysis services, including, but not limited to, Sanger DNA Sequencing, Next Generation sequencing, and microarrays to CFAR investigators. The Genomics component of the core will continue to provide access to state-of-the art genomic technologies, including traditional Sanger DNA sequencing. It will also continue its strong educational component by providing consultative services for the use of high dimensional genomic technologies. 2. Provide state-of-the-art microbiome analysis services to CFAR investigators. The gut microbiome has a major impact on diseases that afflict people with HIV/AIDS including obesity, cardiovascular disease and cancer. The new Microbiome service will provide assistance with experimental design, sample collection and preparation, sequencing and bioinformatics analysis. We have started this program and have already provided service to 19 CFAR members for results that were included in 10 internal and external grant submissions in the first and only year. 3. Provide computational resources and bioinformatics support to assist CFAR investigators in the analysis and understanding of genomic and microbiome data. The Bioinformatics component will continue to provide CFAR investigators with all of the resources necessary to fully support the wide range of informatics needs. Our services provide: 1) access to information;2) access to tools;and 3) research and educational support. 4. Act as a platform for promoting multi-disciplinary research and provide advice and training to CFAR pre- and post-doctoral trainees, pilot project awardees, and investigators regarding general aspects of microbiome and genomics, as well as information on specific measurements, assays, and technologies.

Public Health Relevance

The Genomics Core with new/microbiome and genomic services, coupled with the continued services of Sanger DNA sequencing and computational and bioinformatics support, provides CFAR investigators with unique resources to facilitate research in prevention, pathogenesis, drug discovery and the natural history in the treatment era for HIV/AIDS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI027767-26
Application #
8697466
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
26
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Jones, Robert B; Dorsett, Kaitlyn A; Hjelmeland, Anita B et al. (2018) The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1? signaling. J Biol Chem 293:5659-5667
Dionne-Odom, Jodie; Westfall, Andrew O; Van Der Pol, Barbara et al. (2018) Sexually Transmitted Infection Prevalence in Women With HIV: Is There a Role for Targeted Screening? Sex Transm Dis 45:762-769
Frugé, Andrew D; Van der Pol, William; Rogers, Laura Q et al. (2018) Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial. J Acad Nutr Diet :
Howe, Chanelle J; Dulin-Keita, Akilah; Cole, Stephen R et al. (2018) Evaluating the Population Impact on Racial/Ethnic Disparities in HIV in Adulthood of Intervening on Specific Targets: A Conceptual and Methodological Framework. Am J Epidemiol 187:316-325
Crenshaw, Brennetta J; Gu, Linlin; Sims, Brian et al. (2018) Exosome Biogenesis and Biological Function in Response to Viral Infections. Open Virol J 12:134-148
Trapecar, Martin; Khan, Shahzada; Cohn, Benjamin L et al. (2018) B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection. Mucosal Immunol 11:1158-1167
Sahay, Bikash; Bashant, Kathleen; Nelson, Nicole L J et al. (2018) Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling. Infect Immun 86:
Verma, Richa; Sahu, Rajnish; Dixit, Saurabh et al. (2018) The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic Front Immunol 9:2369
Adeli, Ehsan; Kwon, Dongjin; Zhao, Qingyu et al. (2018) Chained regularization for identifying brain patterns specific to HIV infection. Neuroimage 183:425-437
Crockett, Kaylee B; Turan, Bulent (2018) Moment-to-moment changes in perceived social support and pain for men living with HIV: an experience sampling study. Pain 159:2503-2511

Showing the most recent 10 out of 955 publications