Overall The mission of the UAB CFAR is to support the conduct of cutting-edge research in basic science, therapeutics, prevention, community engaged research, and clinical manifestations and pathogenesis of HIV and related disorders. Five core facilities provide vital support for the Center's principal thematic areas of its scientific agenda. To optimize our CFAR operation, an intensive strategic planning process has established efficiencies through streamlining its cores from 7 to 5, taking full advantage of existing services provided by other centers on campus, outsourcing under-utilized services, and allowing for investments in new areas (Specific Aims workshops, Transplant Tissue Procurement Facility, and Ending HIV in Alabama SWG). The Center includes 185 members from over 30 divisions and departments within UAB. Over the last 4 years, the UAB CFAR has enabled research leading to FRB / total funding of $21M / $66M. The majority (62%) was newly obtained in this budget period; 57% of these are related to basic science, 18% to population health prevention and treatment research, 22% to behavioral epi and intervention research, and 3% to community engaged research. Since our last renewal, the center has increased the number of young investigators supported by training awards from 7 to 16 (14 women; 5 under-represented minorities, URMs) and invested $1.9M in new-investigator pilot awards yielding $25M in outside funding. Overall, for our ROI in pilot funding is 13:1 in new extramural grants awarded. The Center helped recruit 45 new HIV/AIDS investigators in the last 4 years (17 external, 28 new to HIV research), of whom 21 are women and 5 URMs. Across all cores the CFAR supported 61 unique, NIH-funded projects (FRB) and 404 other NIH-funded projects, of which 309 were HIV-specific resulting in over 1000 HIV publications, and in the garnering of strong Institutional support. Over the next 5 years we will: (1) Continue to enhance the productivity of ongoing research programs by enabling interdisciplinary research through the provision of critical shared resource facilities and administrative and fiscal management support to Center investigators (2) Use robust strategic planning methods to identify new research opportunities and priorities that align with existing CFAR programs and foster new research programs where none are in existence, but where faculty interest is evident; (3) Stimulate the entry of early stage and established faculty into HIV/AIDS research programs through mentoring programs for young investigators and through a robust, peer-reviewed Developmental Grants Program; (4) Provide a central focus for HIV/AIDS research activities at UAB that emphasize effective communication and collaboration among CFAR members with the wider HIV/AIDS research community; and (5) Promote faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research in Alabama, the United States, and around the world. The UAB CFAR will foster HIV/AIDS research that has high local, national, and international impact and in so doing will promote the NIH priorities of innovation and effectiveness in AIDS treatment and prevention.

Public Health Relevance

Overall The UAB Center for AIDS Research provides scientific direction, strategic planning, and implementation of services to advance the field of HIV research. The Center powers studies to understand the basic biology of HIV, therapeutic efficacy, and prevention, specifically vaccine development and community based interventions that reduce new transmissions throughout Alabama, the Southeastern United States, and the world.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1)
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Beaubien, Candice M
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University of Alabama Birmingham
Internal Medicine/Medicine
Schools of Medicine
United States
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Crenshaw, Brennetta J; Gu, Linlin; Sims, Brian et al. (2018) Exosome Biogenesis and Biological Function in Response to Viral Infections. Open Virol J 12:134-148
Howe, Chanelle J; Dulin-Keita, Akilah; Cole, Stephen R et al. (2018) Evaluating the Population Impact on Racial/Ethnic Disparities in HIV in Adulthood of Intervening on Specific Targets: A Conceptual and Methodological Framework. Am J Epidemiol 187:316-325
Sahay, Bikash; Bashant, Kathleen; Nelson, Nicole L J et al. (2018) Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling. Infect Immun 86:
Trapecar, Martin; Khan, Shahzada; Cohn, Benjamin L et al. (2018) B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection. Mucosal Immunol 11:1158-1167
Adeli, Ehsan; Kwon, Dongjin; Zhao, Qingyu et al. (2018) Chained regularization for identifying brain patterns specific to HIV infection. Neuroimage 183:425-437
Verma, Richa; Sahu, Rajnish; Dixit, Saurabh et al. (2018) The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic Front Immunol 9:2369
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Crockett, Kaylee B; Turan, Bulent (2018) Moment-to-moment changes in perceived social support and pain for men living with HIV: an experience sampling study. Pain 159:2503-2511
Carson, Tiffany L; Wang, Fuchenchu; Cui, Xiangqin et al. (2018) Associations Between Race, Perceived Psychological Stress, and the Gut Microbiota in a Sample of Generally Healthy Black and White Women: A Pilot Study on the Role of Race and Perceived Psychological Stress. Psychosom Med 80:640-648
Salantes, D Brenda; Zheng, Yu; Mampe, Felicity et al. (2018) HIV-1 latent reservoir size and diversity are stable following brief treatment interruption. J Clin Invest 128:3102-3115

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