Core - Adult Clinical Core Facility

Letvin, Norman L.

Abstract

The Adult Clinical Core at the Beth Israel Hospital will serve to provide clinical specimen to the Dana-Farber Cancer Institute CFAR investigators, facilitate trials of therapies evolving from the basic research of CFAR members and encourage scientific exchange and collaborations between clinical and basic science investigators. The Beth Israel Hospital provides primary care to approximately 480 HIV-infected adults and has extensive NIH funded clinical research programs at the hospital, including a component of the Harvard/Boston City Hospital Aids Clinical Trials Unit (ACTU). The Adult Clinical Core will provide partial support for both a research nurse and a laboratory technician. The research nurse will provide CFAR investigators with clinical specimens from patients and carefully document the clinical histories of these patients for the investigators. The laboratory technician will establish and characterize HIV isolates from patients and maintain a bank of clinical specimens for the use of CFAR investigators. Both the research nurse and laboratory technician will also participate in the trials of therapies initiated through the Dana-Farber Cancer Institute-Beth Israel Hospital interactions. CFAR Cores will be made available to AIDS clinical investigators at the Beth Israel Hospital to strengthen the scientific base of their clinical studies. Finally, joint institutional conferences will be held to foster scientific collaborations and encourage the initiation of clinical trials of novel AIDS therapeutics.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Center Core Grants (P30)
• Project #: 5P30AI028691-14
• Application #: 6652179
• Project Start: 2002-09-01
• Project End: 2003-07-31
• Support Year: 14
• Fiscal Year: 2002

Institution

• Name: Dana-Farber Cancer Institute
• DUNS #: 149617367
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02115

Publications

Liu, Songtao; Fleysher, Roman; Fleysher, Lazar et al. (2010) Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. Magn Reson Med 63:865-71

Liu, Songtao; Gonen, Oded; Fleysher, Roman et al. (2009) Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. Magn Reson Med 62:1292-9

Ratai, Eva-Maria; Pilkenton, Sarah J; Greco, Jane B et al. (2009) In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain. BMC Neurosci 10:63

Gonen, Oded; Liu, Songtao; Goelman, Gadi et al. (2008) Proton MR spectroscopic imaging of rhesus macaque brain in vivo at 7T. Magn Reson Med 59:692-9

Ratai, Eva-Maria; Hancu, Ileana; Blezek, Daniel J et al. (2008) Automatic repositioning of MRSI voxels in longitudinal studies: impact on reproducibility of metabolite concentration measurements. J Magn Reson Imaging 27:1188-93

Liu, Songtao; Gonen, Oded; Fleysher, Lazar et al. (2008) Regional metabolite T2 in the healthy rhesus macaque brain at 7T. Magn Reson Med 59:1165-9

Li, Xing; Gold, Bert; O'hUigin, Colm et al. (2007) Unique features of TRIM5alpha among closely related human TRIM family members. Virology 360:419-33

Javanbakht, Hassan; Yuan, Wen; Yeung, Darwin F et al. (2006) Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid binding. Virology 353:234-46

Diaz-Griffero, Felipe; Vandegraaff, Nick; Li, Yuan et al. (2006) Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1. Virology 351:404-19

Koralnik, Igor J (2006) Progressive multifocal leukoencephalopathy revisited: Has the disease outgrown its name? Ann Neurol 60:162-73