This application constitutes a renewal for a Center for AIDS Research (CFAR) grant, for the CFAR established at UCLA in September, 1991. Although this application constitutes a renewal, our current CFAR is funded for a total of only three years, compared to the other CFARs, which were funded for five years. At the time of submission of this application, we have been in operation for only two years. The overall research theme of the UCLA CFAR is promotion of research into HIV-1 pathogenesis and immune function and dysfunctions in AIDS and HIV infection. This CFAR is specifically designed to promote and facilitate basic science research efforts and to catalyze new areas of investigation at the basic and clinical science level. The Director is Dr. Irvin S.Y. Chen, nd the Co-Director is Dr. Ronald Mitsuyasu. This CFAR consist of the Administrative Core; the Developmental Core; three laboratory cores, """"""""Virology/BSL3 Tissue Culture"""""""", """"""""Flow Cytometry/Cell Sorting"""""""" and """"""""SCID Mouse/Human Chimera""""""""; and two clinical cores, """"""""Clinical/Basic Sciences Interface"""""""" and """"""""Gene and Cellular Therapy""""""""; as well as internal and external advisory committees. We are focused on two major research strengths at UCLA which complement a strong clinical trials unit under the direction of the CFAR Co-Director, Dr. Ronald Mitsuyasu. These two research strengths are: 1) investigations into viral pathogenesis; and 2) immune function and restoration, including cytokine research and gene therapy. We envision that this CFAR will provide a structure for innovation, leading to greater understanding of HIV-1 pathogenesis and immune function through interdisciplinary interactions and collaborations. In time, these advances and research will lead to novel therapeutic approaches. The overall goals of the CFAR are to: 1. Promote innovative ideas about new therapeutic approaches through an understanding of basic pathogenic and immunologic aspects of HIV-1 disease. 2. Promote multidisciplinary research approaches involving virology, immunology, animal models and basic studies of HIV pathogenesis. 3. Promote interdisciplinary basic/clinical science approaches to AIDS research, with a particular emphasis on facilitating development of basic science advances toward novel diagnostic, therapeutic and preventative approaches to HIV disease (""""""""transnational"""""""" research). The Funded Research Base for this CFAR consists of 17 NIAID-funded projects, totalling $6,531,384. In total, there are 43 CFAR investigators, both NIAID and non-NIAID, who may use CFAR resources,l demonstrating the breadth of AIDS research activities to be supported by the UCLA CFAR.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (SRC (71))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
Zip Code
Shannon, Chelsea Lee; Bristow, Claire; Hoff, Nicole et al. (2018) Acceptability and Feasibility of Rapid Chlamydial, Gonococcal, and Trichomonal Screening and Treatment in Pregnant Women in 6 Low- to Middle-Income Countries. Sex Transm Dis 45:673-676
Furler, Robert L; Nixon, Douglas F; Brantner, Christine A et al. (2018) TGF-? Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction. Cancers (Basel) 10:
Sato, Kei; Misawa, Naoko; Takeuchi, Junko S et al. (2018) Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model. J Virol 92:
Leoh, Lai Sum; Kim, Yoon Kyung; Candelaria, Pierre V et al. (2018) Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma. J Immunol 200:3485-3494
Heard, Jeffrey J; Phung, Ivy; Potes, Mark I et al. (2018) An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation. BMC Cancer 18:69
Young, Sean D; Mercer, Neil; Weiss, Robert E et al. (2018) Using social media as a tool to predict syphilis. Prev Med 109:58-61
Kim, Roy Y; Mangu, Darian; Hoffman, Alexandria S et al. (2018) Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis. Brain 141:132-147
Hicks, Michael R; Hiserodt, Julia; Paras, Katrina et al. (2018) ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nat Cell Biol 20:46-57
Allan-Blitz, Lao-Tzu; Herrera, M Christina; Calvo, Gino M et al. (2018) Venue-Based HIV-Testing: An Effective Screening Strategy for High-Risk Populations in Lima, Peru. AIDS Behav :
Daniels, Joseph; Marlin, Robert; Medline, Alex et al. (2018) Getting HIV Self-Test Kits into the Home for Young African American MSM in Los Angeles: A Qualitative Report. J Assoc Nurses AIDS Care 29:115-119

Showing the most recent 10 out of 942 publications