Abstract

The SCID-hu Mouse/Human Chimera Core Facility is designed to provide access to state-of-the-art-mouse/human chimera technology for UCLA- affiliated AIDS investigators. This facility will provide breeding of SCID mice at a reduced rate, housing for SCID mice, and a BSL3 laboratory for manipulation and housing of chimeric mice infected with human retroviruses. Consultation on construction of mouse/human chimeras (hu- PBL-SCID and SCID-hu) is also available. In addition, there is a developmental component to this core, which has helped to established the SCID-hu mouse as an in vivo model for virus-induced pathology. This component approaches to combat AIDS, and will participate in development of a model for growth of human brain tissue in vivo. This latter system will be used to investigate mechanisms of neuropathogenesis of AIDS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI028697-05
Application #
3727262
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Degtyar, Aleksandra; George, Paul E; Mallma, Patricia et al. (2018) Sexual Risk, Behavior, and HIV Testing and Status among Male and Transgender Women Sex Workers and their Clients in Lima, Peru. Int J Sex Health 30:81-91
Dovel, Kathryn; Shaba, Frackson; Nyirenda, Mike et al. (2018) Evaluating the integration of HIV self-testing into low-resource health systems: study protocol for a cluster-randomized control trial from EQUIP Innovations. Trials 19:498
DeVost, Michelle A; Beymer, Matthew R; Weiss, Robert E et al. (2018) App-Based Sexual Partner Seeking and Sexually Transmitted Infection Outcomes: A Cross-Sectional Study of HIV-Negative Men Who Have Sex With Men Attending a Sexually Transmitted Infection Clinic in Los Angeles, California. Sex Transm Dis 45:394-399
Balamurugan, Arumugam; Ng, Hwee L; Yang, Otto O (2018) Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones. J Virol 92:
Seang, Sophie; Kelesidis, Theodoros; Huynh, Diana et al. (2018) Low Levels of Endothelial Progenitor Cells and Their Association with Systemic Inflammation and Monocyte Activation in Older HIV-Infected Men. AIDS Res Hum Retroviruses 34:39-45
Kojima, Noah; Klausner, Jeffrey D (2018) Fight Fire With Fire: Innovations to Address Syphilis Among Men Who Have Sex With Men. Sex Transm Dis 45:e85-e86
Black, David S; Cole, Steve W; Christodoulou, Georgia et al. (2018) Genomic mechanisms of fatigue in survivors of colorectal cancer. Cancer 124:2637-2644
Ziyad, Safiyyah; Riordan, Jesse D; Cavanaugh, Ann M et al. (2018) A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis. Cell Rep 22:1211-1224
Walser, Tonya C; Jing, Zhe; Tran, Linh M et al. (2018) Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells. Cancer Res 78:1986-1999
Fulcher, Jennifer A; Shoptaw, Steven; Makgoeng, Solomon B et al. (2018) Brief Report: Recent Methamphetamine Use Is Associated With Increased Rectal Mucosal Inflammatory Cytokines, Regardless of HIV-1 Serostatus. J Acquir Immune Defic Syndr 78:119-123

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