Abstract

The SCID-hu Mouse/Human Chimera Core Facility is designed to provide access to state-of-the-art-mouse/human chimera technology for UCLA- affiliated AIDS investigators. This facility will provide breeding of SCID mice at a reduced rate, housing for SCID mice, and a BSL3 laboratory for manipulation and housing of chimeric mice infected with human retroviruses. Consultation on construction of mouse/human chimeras (hu- PBL-SCID and SCID-hu) is also available. In addition, there is a developmental component to this core, which has helped to established the SCID-hu mouse as an in vivo model for virus-induced pathology. This component approaches to combat AIDS, and will participate in development of a model for growth of human brain tissue in vivo. This latter system will be used to investigate mechanisms of neuropathogenesis of AIDS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI028697-06
Application #
5205396
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Swendeman, Dallas; Fehrenbacher, Anne E; Roy, Soma et al. (2018) Gender disparities in depression severity and coping among people living with HIV/AIDS in Kolkata, India. PLoS One 13:e0207055
Beymer, Matthew R; Kofron, Ryan M; Tseng, Chi-Hong et al. (2018) Results from the post-exposure prophylaxis pilot program (P-QUAD) demonstration project in Los Angeles County. Int J STD AIDS 29:557-562
Matassoli, Flávio Lemos; Leão, Ihid Carneiro; Bezerra, Bruno Braz et al. (2018) Hydroxypropyl-Beta-Cyclodextrin Reduces Inflammatory Signaling from Monocytes: Possible Implications for Suppression of HIV Chronic Immune Activation. mSphere 3:
Ramos, Juan C; Sparano, Joseph A; Rudek, Michelle A et al. (2018) Safety and Preliminary Efficacy of Vorinostat With R-EPOCH in High-risk HIV-associated Non-Hodgkin's Lymphoma (AMC-075). Clin Lymphoma Myeloma Leuk 18:180-190.e2
Jia, Qingmei; Bowen, Richard; Dillon, Barbara Jane et al. (2018) Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. Sci Rep 8:7009
Woo, Jin Seok; Srikanth, Sonal; Kim, Kyun-Do et al. (2018) CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol 201:1174-1185
Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
Arfer, Kodi B; Tomlinson, Mark; Mayekiso, Andile et al. (2018) Criterion validity of self-reports of alcohol, cannabis, and methamphetamine use among young men in Cape Town, South Africa. Int J Ment Health Addict 16:45-52
Furler, Robert L; Nixon, Douglas F; Brantner, Christine A et al. (2018) TGF-? Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction. Cancers (Basel) 10:
Shannon, Chelsea Lee; Bristow, Claire; Hoff, Nicole et al. (2018) Acceptability and Feasibility of Rapid Chlamydial, Gonococcal, and Trichomonal Screening and Treatment in Pregnant Women in 6 Low- to Middle-Income Countries. Sex Transm Dis 45:673-676

Showing the most recent 10 out of 942 publications