This application constitutes a renewal on the part of the University of California Los Angeles (UCLA) for a Center for AIDS Research (CFAR) grant. This grant will fund activities and programs conducted by the UCLA CFAR within the UCLA AIDS Institute. The UCLA CFAR was set up in 1988, and the AIDS Institute was established in 1992 to coordinate all AIDS research, clinical and educational activities at the University and its affiliated teaching hospitals under one central administration. The overall organization of the AIDS Institute and the CFAR was restructured in 2005, in order to more efficiently and effectively manage the AIDS research activities with a bottom-up approach to governance, allowing participation by all faculty in all of our programs. This renewal application includes CFAR core services and activities that are designed to advance knowledge of HIV/AIDS through the basic, clinical, and behavioral sciences. The overall mission of the UCLA CFAR is to create synergies among diverse disciplines that result in significant breakthroughs in the understanding, prevention and treatment of HIV infection-with particular emphasis on high-value cross disciplinary collaborations. The UCLA CFAR consists of more than 200 investigators who are responsible for research projects that encompass virtually all aspects of HIV/AIDS biology, clinical studies, and behavioral science. UCLA has consistently been ranked among the top institutions for excellence in AIDS research, education and teaching, and clinical programs. The role of the CFAR is to foster collaboration and build linkages both within and outside the university, through support of scientific and administrative core facilities, and the provision of seed grant funding for highly meritorious collaborative and interdisciplinary research projects. The action plan for the first year of requested support is summarized as follows: The CFAR plans to continue supporting nine of the cores funded by the previous CFAR grant: Administrative Core, Developmental Core, Virology/BSL3 Tissue Culture Core, Cytometry Core, Humanized Mouse Core, Gene and Cellular Therapy Core, Mucosal Immunology Core, a Clinical Research Facilitation Core and the Biostatistics Core. Based upon changing epidemiology, needs assessments, strategic planning and revised short-and long-term goals, one core was eliminated and we developed an HIV+ and HIV- subject registry through our Clinical Research Facilitation Core. Inclusion of this resource will be highly beneficial to clinical, behavioral and basic science studies.
Research into the pathogenesis, treatment and social aspects of HIV disease is needed to end this epidemic. Our program is designed to integrate clinical, behavioral and basic sciences and to provide valuable core services to facilitate AIDS research. Metropolitan Los Angeles is a major epicenter for the AIDS epidemic and one of the most culturally diverse regions in the nation, and our programs are designed to reach out to these diverse communities. We are particularly proud that 50% of the patients recruited into our clinical trials in recent years are members of minority communities particularly hard hit by this disease.
|Furler, Robert L; Nixon, Douglas F; Brantner, Christine A et al. (2018) TGF-? Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction. Cancers (Basel) 10:|
|Shannon, Chelsea Lee; Bristow, Claire; Hoff, Nicole et al. (2018) Acceptability and Feasibility of Rapid Chlamydial, Gonococcal, and Trichomonal Screening and Treatment in Pregnant Women in 6 Low- to Middle-Income Countries. Sex Transm Dis 45:673-676|
|Leoh, Lai Sum; Kim, Yoon Kyung; Candelaria, Pierre V et al. (2018) Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma. J Immunol 200:3485-3494|
|Sato, Kei; Misawa, Naoko; Takeuchi, Junko S et al. (2018) Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model. J Virol 92:|
|Young, Sean D; Mercer, Neil; Weiss, Robert E et al. (2018) Using social media as a tool to predict syphilis. Prev Med 109:58-61|
|Heard, Jeffrey J; Phung, Ivy; Potes, Mark I et al. (2018) An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation. BMC Cancer 18:69|
|Hicks, Michael R; Hiserodt, Julia; Paras, Katrina et al. (2018) ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nat Cell Biol 20:46-57|
|Kim, Roy Y; Mangu, Darian; Hoffman, Alexandria S et al. (2018) Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis. Brain 141:132-147|
|Allan-Blitz, Lao-Tzu; Herrera, M Christina; Calvo, Gino M et al. (2018) Venue-Based HIV-Testing: An Effective Screening Strategy for High-Risk Populations in Lima, Peru. AIDS Behav :|
|Daniels, Joseph; Marlin, Robert; Medline, Alex et al. (2018) Getting HIV Self-Test Kits into the Home for Young African American MSM in Los Angeles: A Qualitative Report. J Assoc Nurses AIDS Care 29:115-119|
Showing the most recent 10 out of 942 publications