The current UCSD CFAR is a component of the AID Research Institute, an Organized Research Unit in the University of California System. We propose to expand the CFAR into a regional, comprehensive AIDS Research Center, with participating members drawn from UCSD and neighboring institutions including the Salk Institute, Scripps Research Foundation, the Burnham Cancer Research Foundation, and the La Jolla Institute for Allergy and Immunology. Dr. Flossie Wong-Staal and Dr. Douglas Richman will continue to serve as the Director and Co-director of the new Center. Their cooperation and complementary areas of expertise should strengthen the interaction of basic and clinical AIDS research as well as ensuring a continuation in leadership. The central mission of the new CFAR is to develop improved vaccines and therapies for HIV infection and associated disease through: (i) Basic Research in the areas of molecular pathogenesis and immunopathogenesis of HIV infection; (ii) Utilization of insights from basic research to develop pre-clinical and clinical trials of therapies and vaccines; (iii) Further clinical research to address fundamental scientific and practical medical issues; (iv) Providing leadership and serving as a regional resource to coordinate, stimulate and cross- fertilize all of the above to foster synergism, economies of scale and novel and creative approaches. The new CFAR will have a greatly strengthened Administrative Core to effectively coordinate the diverse activities of the Center. The Developmental Core will also be expanded in accordance with the growth in participating membership from neighboring institutions. A number of new cores will be established to keep pace with current needs and research activities on HIV. The proposed cores include five basic sciences cores: Molecular Biology, Virology, Flow Cytometry, Gene Therapy and Signal Transduction/Apoptosis and four clinical cores: Clinical Data and Outcomes, Clinical Investigation, Behavioral and Health Function and Primary Isolation and Specimen Banking. In addition, we will have access to a number of core facilities at different sites that are not directly funded by CFAR. A set of policies and procedures has been established to evaluate the performance of each core and to guide decisions in funding reallocation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI036214-06
Application #
2627906
Study Section
Special Emphasis Panel (ZAI1-SCO-A (J1))
Project Start
1994-04-01
Project End
2001-02-28
Budget Start
1998-09-01
Budget End
1999-02-28
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Lin, Timothy C; Burton, Brittany N; Barleben, Andrew et al. (2018) Association of HIV infection with age and symptomatic carotid atherosclerotic disease at the time of carotid intervention in the United States. Vasc Med 23:467-475
Singh, Rajendra; Stoneham, Charlotte; Lim, Christopher et al. (2018) Phosphoserine acidic cluster motifs bind distinct basic regions on the ? subunits of clathrin adaptor protein complexes. J Biol Chem 293:15678-15690
Guise, Andy; Melo, Jason; Mittal, Maria Luisa et al. (2018) A fragmented code: The moral and structural context for providing assistance with injection drug use initiation in San Diego, USA. Int J Drug Policy 55:51-60
Bekker, Linda-Gail; Alleyne, George; Baral, Stefan et al. (2018) Advancing global health and strengthening the HIV response in the era of the Sustainable Development Goals: the International AIDS Society-Lancet Commission. Lancet 392:312-358
Stecher, Melanie; Chaillon, Antoine; Eberle, Josef et al. (2018) Molecular Epidemiology of the HIV Epidemic in Three German Metropolitan Regions - Cologne/Bonn, Munich and Hannover, 1999-2016. Sci Rep 8:6799
de Almeida, Sérgio M; Tang, Bin; Ribeiro, Clea E et al. (2018) Neprilysin in the Cerebrospinal Fluid and Serum of Patients Infected With HIV1-Subtypes C and B. J Acquir Immune Defic Syndr 78:248-256
Giamouridis, Dimosthenis; Gao, Mei Hua; Lai, N Chin et al. (2018) Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal. JACC Basic Transl Sci 3:249-264
Jenks, Jeffrey D; Reed, Sharon L; Seidel, Danila et al. (2018) Rare mould infections caused by Mucorales, Lomentospora prolificans and Fusarium, in San Diego, CA: the role of antifungal combination therapy. Int J Antimicrob Agents 52:706-712
Drumright, Lydia N; Weir, Sharon S; Frost, Simon D W (2018) The role of venues in structuring HIV, sexually transmitted infections, and risk networks among men who have sex with men. BMC Public Health 18:225
Francesconi, Walter; Berton, Fulvia; Marcondes, Maria Cecilia G (2018) HIV-1 Tat alters neuronal intrinsic excitability. BMC Res Notes 11:275

Showing the most recent 10 out of 921 publications