The Viral Pathogenesis Core serves as a centralized source for isolates and assays related to HIV-1, HIV-2, and SIV. In addition, the Core acts as an interface between users and the laboratories of UCSD CFAR members specializing in the herpes virus affecting HIV-infected individuals (CMV, HSV, and HHV-8). Four basic types of services are provided: (1) As a viral resource, the Core provides aliquots from a wide collection of characterized and titered viral strains of HIV-1, HIV-2, and SIV. (2) As a cell resource, the Core provides virus susceptible cells, including cell lines, isolated CD4+ T cells and macrophages. (3) As a virus characterization resource, the Core provides testing for cell tropisms, syncytium-inducing (SI) versus non-SI, co-receptor usage, cytopathic versus non-cytopathic, replication kinetics, drug susceptibilities, and other properties of HIV. (4) As a screening service, the Core provides the initial testing for investigational therapeutics (antiviral compounds, gene therapies, antibody neutralization, etc.). These resources make it easier for both novices and experienced investigators to pursue their virological research ideas. Without the Core, each investigator would need to set up and validate the different methods and assays required for their work, which could take months. Also, many of the Core's users have no BL3 training or experience themselves, and thus would need to expend months of effort on gaining the permission needed to work with these viruses. While the Core is not meant to replace a full scale research program set up by an investigator as one of the major projects, it is ideal for conducting pilot experiments and the screening of compounds for antiviral activity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI036214-06
Application #
6268171
Study Section
Project Start
1998-09-01
Project End
1999-02-28
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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