Abstract

The gene therapy core will support growing interest in the use of lentivirus-based retroviral vectors. HIV-based lentiviral vectors and standard oncoretrovirus-derived vectors will be provided for experimental studies of lentiviral biology, including studies of non-dividing and post- mitotic target cells. Investigations into the potential of these vectors for therapeutic gene transfer will also be enabled. In addition, assistance with the design, regulatory review and implementation of human gene therapy trials will be provided. The Core will employ a full time technician who will assist with services that include maintenance and cryopreservation of cell lines, preparation and use of plasmids and transfection reagents, transfection, vector harvest, cryopreservation and titration, assays for replication-competent retrovirus, record keeping for vector stocks and cell lines, and facilitation of communication and materials transfer to investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036214-08
Application #
6299722
Study Section
Project Start
2000-03-01
Project End
2002-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
2000
Total Cost
$100,663
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Rhodes, Tim (2018) The becoming of methadone in Kenya: How an intervention's implementation constitutes recovery potential. Soc Sci Med 201:71-79
Morales, Mario; Rafful, Claudia; Gaines, Tommi L et al. (2018) Factors associated with extrajudicial arrest for syringe possession: results of a department-wide survey of municipal police in Tijuana, Mexico. BMC Int Health Hum Rights 18:36
Ben Hamida, Amen; Rafful, Claudia; Jain, Sonia et al. (2018) Non-injection Drug Use and Injection Initiation Assistance among People Who Inject Drugs in Tijuana, Mexico. J Urban Health 95:83-90
Christensen-Quick, Aaron; Chaillon, Antoine; Yek, Christina et al. (2018) Influenza Vaccination Can Broadly Activate the HIV Reservoir During Antiretroviral Therapy. J Acquir Immune Defic Syndr 79:e104-e107
Groessl, Erik J; Ganiats, Theodore G; Hillery, Naomi et al. (2018) Cost analysis of rapid diagnostics for drug-resistant tuberculosis. BMC Infect Dis 18:102
Dillon, Stephanie M; Guo, Kejun; Austin, Gregory L et al. (2018) A compartmentalized type I interferon response in the gut during chronic HIV-1 infection is associated with immunopathogenesis. AIDS 32:1599-1611
Goldenberg, Shira M; Rocha Jiménez, Teresita; Brouwer, Kimberly C et al. (2018) Influence of indoor work environments on health, safety, and human rights among migrant sex workers at the Guatemala-Mexico Border: a call for occupational health and safety interventions. BMC Int Health Hum Rights 18:9
Mehta, Sanjay R; Chaillon, Antoine; Gaines, Tommi L et al. (2018) Impact of Public Safety Policies on Human Immunodeficiency Virus Transmission Dynamics in Tijuana, Mexico. Clin Infect Dis 66:758-764
Fraser, Hannah; Zibbell, Jon; Hoerger, Thomas et al. (2018) Scaling-up HCV prevention and treatment interventions in rural United States-model projections for tackling an increasing epidemic. Addiction 113:173-182
Dinesha, T R; Boobalan, J; Sivamalar, S et al. (2018) Occult HBV infection in HIV-infected adults and evaluation of pooled NAT for HBV. J Viral Hepat 25:718-723

Showing the most recent 10 out of 921 publications