The CWRU CFAR Clinical Research Core Facility will enhance AIDS Research Activities at CWRU by providing access to patients, clinical samples, the Special Immunology Unit Data Base and resources of the CWRU AIDS Clinical Trials Unit. The four main components of the Facility (Special Immunology Unit, Special Immunology Unit Data Base, AIDS Clinical Trials Unit and Outreach Educational Program) provide the means to optimize and promote collaboration between clinical and basic AIDS research at CWRU. University Hospitals Special Immunology Unit (SIU) is the largest HIV- care facility in Northeast Ohio and one of the largest in the Midwest. The SIU now provides high levels HIV-care to over 600 persons regardless of their financial resources. Moreover it is recognized in the community for outstanding service and therefore provides service to persons from all risk groups for HIV; its patients population is representative of the racial and ethnic diversity of our region. Through the novel 3- dimensional and interactive SIU Data Base, clinical and basic researchers can rapidly identify patients eligible for participation in clinical trials or clinical research projects. The data base (containing information on over 1,000 HIV+ patients having received care at CWRU) also provides an invaluable resource for descriptive or epidemiologic studies. Access to patients and patient specimens will be provided by the Clinical Core Study Coordinator who will identify eligible patients, explain the project, obtain informed consent, coordinate appointments among patients, staff and laboratory personnel, obtain and coordinate delivery of specimens to the appropriate laboratory. The CWRU AIDS Clinical Trials Unit is recognized within the ACTG for its outstanding performance in AIDS Clinical Trials. Access to resources of the ACTG- certified Virology and Immunology Laboratories, well-defined patient populations participating in clinical treatment trials, and the expertise of the ACTU investigators and staff in clinical trials design, implementation and data management-will facilitate coordination of basic and clinical AIDS research. In order to disseminate information about AIDS and AIDS research to the general public, community leaders and population with or at risk for HIV, a targeted Outreach Program has been developed. The details of each aspect of the Outreach Program will be tailored to each target population. The Program will be supervised by the Center staff who have developed credibility as recognized authorities and leaders in the community response to AIDS. The Outreach Program will develop a broader community understanding about HIV and AIDS research, fostering an atmosphere supportive of AIDS research and clinical trials in Northeast Ohio.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
1P30AI036219-04
Application #
6235261
Study Section
Project Start
1997-04-01
Project End
1998-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Mbonye, Uri; Wang, Benlian; Gokulrangan, Giridharan et al. (2018) Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation. J Biol Chem 293:10009-10025
Sayin, Ismail; Radtke, Andrea J; Vella, Laura A et al. (2018) Spatial distribution and function of T follicular regulatory cells in human lymph nodes. J Exp Med 215:1531-1542
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Martinez, Leonardo; Shen, Ye; Handel, Andreas et al. (2018) Effectiveness of WHO's pragmatic screening algorithm for child contacts of tuberculosis cases in resource-constrained settings: a prospective cohort study in Uganda. Lancet Respir Med 6:276-286
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Kityo, Cissy; Makamdop, Krystelle Nganou; Rothenberger, Meghan et al. (2018) Lymphoid tissue fibrosis is associated with impaired vaccine responses. J Clin Invest 128:2763-2773
Wiredja, Danica D; Tabler, Caroline O; Schlatzer, Daniela M et al. (2018) Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells. Retrovirology 15:44
Oliveira, Vitor H F; Perazzo, Joseph D; Josephson, Richard A et al. (2018) Association Between the 6-Minute Walk Test Distance and Peak Cardiorespiratory Fitness Among People Living with HIV Varies by Fitness Level. J Assoc Nurses AIDS Care 29:775-781
Paparisto, Ermela; Woods, Matthew W; Coleman, Macon D et al. (2018) Evolution-Guided Structural and Functional Analyses of the HERC Family Reveal an Ancient Marine Origin and Determinants of Antiviral Activity. J Virol 92:
Llewellyn, George N; Alvarez-Carbonell, David; Chateau, Morgan et al. (2018) HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol 24:192-203

Showing the most recent 10 out of 539 publications