Abstract

The Developmental Core is an essential tool used by the Case CFAR to provide support for innovative and successful AIDS-related research activities. The Core has an impressive track record in identifying key focus areas in AIDS research and engaging junior faculty through direct/hands-on mentoring. During the last grant cycle current Asst. Profs. Donald Anthony, David Canaday, David McDonald, Yong Gao, Michael Cho and Scott Sieg were supported by CFAR developmental awards, mentored by senior CFAR faculty, and have now developed strong, independent research programs. These pilot project awards proved absolutely necessary for junior faculty to obtain sufficient preliminary data for an R series NIH grant award. Over the last 5 years the 22 CFAR-supported pilot projects, with a total investment of $712,000, have been leveraged into $11.7 million in NIH and non-NIH grants, or a 16.7-fold return on investment Members of the CFAR Developmental Core scientific review committee take pride in the past success of these junior faculty. To further build on these successes, we have now implemented a formalized mentoring process overseen by the Developmental Core. In addition, in close collaboration with the Administrative Core, Core B works to expand the CFAR membership by providing resources for the recruitment of new faculty and the engagement of faculty who have not previously been involved in HIV/AIDS research in collaborative projects. Finally, Core B interacts with each of the laboratory Cores in the CFAR by providing a scientific review mechanism used to evaluate new capital equipment purchases and project-based core services awards. The Core achieves these objectives through the following mechanisms: ? Junior investigator-initiated pilot project awards and allied mentorship program ? Targeted pilot project awards in areas of high strategic priority ? New faculty recruitment and engagement of senior faculty in HIV/AIDS research ? support for CFAR cores through strategic investments

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036219-19
Application #
8463972
Study Section
Special Emphasis Panel (ZAI1-JBS-A)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
19
Fiscal Year
2013
Total Cost
$258,652
Indirect Cost
$89,549

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Webel, Allison R; Perazzo, Joseph; Longenecker, Christopher T et al. (2018) The Influence of Exercise on Cardiovascular Health in Sedentary Adults With Human Immunodeficiency Virus. J Cardiovasc Nurs 33:239-247
Yan, Junpeng; Shun, Ming-Chieh; Hao, Caili et al. (2018) HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection. MBio 9:
Silver, Nicholas; Paynter, Mary; McAllister, Georgina et al. (2018) Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay. AIDS Res Ther 15:18
Jiang, Wei; Luo, Zhenwu; Martin, Lisa et al. (2018) Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy. Curr HIV Res 16:143-150
Martinez, Leonardo; Handel, Andreas; Shen, Ye et al. (2018) A Prospective Validation of a Clinical Algorithm to Detect Tuberculosis in Child Contacts. Am J Respir Crit Care Med 197:1214-1216
Fitzgerald, Wendy; Freeman, Michael L; Lederman, Michael M et al. (2018) A System of Cytokines Encapsulated in ExtraCellular Vesicles. Sci Rep 8:8973
Dazard, Jean-Eudes; Ishwaran, Hemant; Mehlotra, Rajeev et al. (2018) Ensemble survival tree models to reveal pairwise interactions of variables with time-to-events outcomes in low-dimensional setting. Stat Appl Genet Mol Biol 17:
Mukherjee, Pranab K; Chandra, Jyotsna; Retuerto, Mauricio et al. (2018) Dysbiosis in the oral bacterial and fungal microbiome of HIV-infected subjects is associated with clinical and immunologic variables of HIV infection. PLoS One 13:e0200285
Bengtson, Angela M; Pence, Brian W; Eaton, Ellen F et al. (2018) Patterns of efavirenz use as first-line antiretroviral therapy in the United States: 1999-2015. Antivir Ther 23:363-372
Tomalka, Amanda G; Resto-Garay, Ivelisse; Campbell, Kerry S et al. (2018) In vitro Evidence That Combination Therapy With CD16-Bearing NK-92 Cells and FDA-Approved Alefacept Can Selectively Target the Latent HIV Reservoir in CD4+ CD2hi Memory T Cells. Front Immunol 9:2552

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