Core B ? Developmental Core The CWRU/UH CFAR Developmental Core stimulates innovative investigator-initiated HIV/AIDS- related clinical and basic science research activities. The Developmental Core is the focus for all of the mentoring and training activities of the CFAR. The key program administered by the Core are the award of pilot grants of $50,000 to early-career investigators that are linked to one-on-one mentoring programs designed to enhance our junior faculty's competitiveness for federal grants. Since 2008, the CFAR has invested $1,183,068 in its Mentored Scientist Pilot Grants. Our awardees have received $19,423,434 in research funding as a result of their awards or a 16.4-fold return on investment. The Core has continued to expand its mentoring programs by providing both one-on-one mentoring and a series of mentoring workshops targeting CFAR pilot grant applicants/awardees, as well as underrepresented minority researchers. To give just a few examples, in the last funding cycle CFAR junior faculty Drs. Tilton and Ye, who were supported by CFAR pilot awards, each received NIH funding and established strong independent translational research programs that bridge clinical and basic research departments at CWRU, thus providing a value-added component. Our institutionally-supported catalytic fund provides $75,000 seed funding for strategically important multidisciplinary projects in which junior faculty take a leading role. While the pilot awards use NIH funds to support single investigator projects by new investigators, the Catalytic Fund, which exclusively uses institutional funds, supports teams that include outstanding young investigators in a leading role and also include established investigators. In the inaugural year we funded 3 catalytic fund multi-investigator projects, each of which includes a junior investigator in a leadership role. A total commitment of $1.25 M has been made to this program.
The specific aims of the Core are as follows: Conduct responsive Pilot Grant and Catalytic Fund programs that accelerate junior faculty development. Identify, mentor, and support the next generations of HIV investigators. Inspire postdoctoral fellows, graduate students and undergraduates and provide Minority Training Programs. Engage the communities we serve. Train and provide support to HIV/AIDS researchers in the planning and conduct of ethically sound research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI036219-25
Application #
9690565
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
25
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Martinez, Leonardo; Shen, Ye; Handel, Andreas et al. (2018) Effectiveness of WHO's pragmatic screening algorithm for child contacts of tuberculosis cases in resource-constrained settings: a prospective cohort study in Uganda. Lancet Respir Med 6:276-286
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Kityo, Cissy; Makamdop, Krystelle Nganou; Rothenberger, Meghan et al. (2018) Lymphoid tissue fibrosis is associated with impaired vaccine responses. J Clin Invest 128:2763-2773
Wiredja, Danica D; Tabler, Caroline O; Schlatzer, Daniela M et al. (2018) Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells. Retrovirology 15:44
Oliveira, Vitor H F; Perazzo, Joseph D; Josephson, Richard A et al. (2018) Association Between the 6-Minute Walk Test Distance and Peak Cardiorespiratory Fitness Among People Living with HIV Varies by Fitness Level. J Assoc Nurses AIDS Care 29:775-781
Paparisto, Ermela; Woods, Matthew W; Coleman, Macon D et al. (2018) Evolution-Guided Structural and Functional Analyses of the HERC Family Reveal an Ancient Marine Origin and Determinants of Antiviral Activity. J Virol 92:
Llewellyn, George N; Alvarez-Carbonell, David; Chateau, Morgan et al. (2018) HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol 24:192-203
Longenecker, Chris T; Sullivan, Claire E; Morrison, Justin et al. (2018) The effects of HIV and smoking on aortic and splenic inflammation. AIDS 32:89-94
Tomas, Myreen E; Mana, Thriveen S C; Wilson, Brigid M et al. (2018) Tapering Courses of Oral Vancomycin Induce Persistent Disruption of the Microbiota That Provide Colonization Resistance to Clostridium difficile and Vancomycin-Resistant Enterococci in Mice. Antimicrob Agents Chemother 62:

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