Abstract

This Application seeks renewal of the Center for AIDS Research (CFAR) at the University of Massachusetts Medical School (UMASS) initially established in September of 1998. The CFAR provides the organizational framework to enhance and coordinate AIDS-related research at the Institution. The Developmental Core (Core B) provides new investigator support, as well as promoting the initiation of collaborative and translational research projects. Basic research and translational research are coordinated and supported by Clinical, Molecular Virology , Molecular Biology, and Animal Models (Core F) cores. The CFAR enhances other established programs at the Institution including AIDS Clinical Trials groups as well as NIAID-funded doctoral and post-doctoral training programs in Immunology and Virology. The CFAR is directed by Mario Stevenson, Ph.D., with Ronald Desrosiers, Ph.D. and John Sullivan, M.D. serving as CFAR Co-Directors. Through the advice of Internal and External Advisory committees, the CFAR keeps pace with the changing needs of AIDS researchers at the Institution.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI042845-09
Application #
7084497
Study Section
Special Emphasis Panel (ZAI1-HSD-A (J1))
Program Officer
Namkung, Ann S
Project Start
1998-09-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
9
Fiscal Year
2006
Total Cost
$914,347
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655

  Publications

Gonzalez-Perez, Maria Paz; Peters, Paul J; O'Connell, Olivia et al. (2017) Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications. J Virol 91:
Ambade, Aditya; Satishchandran, Abhishek; Szabo, Gyongyi (2016) Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1? activation. Sci Rep 6:21340
Peters, Paul J; Gonzalez-Perez, Maria Paz; Musich, Thomas et al. (2015) Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes. Retrovirology 12:48
Fouda, Genevieve G; Cunningham, Coleen K; McFarland, Elizabeth J et al. (2015) Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses. J Infect Dis 211:508-17
Musich, Thomas; O'Connell, Olivia; Gonzalez-Perez, Maria Paz et al. (2015) HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages. Retrovirology 12:25
Gibson, Laura; Barysauskas, Constance M; McManus, Margaret et al. (2015) Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection. J Clin Immunol 35:289-301
Greenough, Thomas C; Straubhaar, Juerg R; Kamga, Larisa et al. (2015) A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection. J Immunol 195:4185-97
Brehm, Michael A; Wiles, Michael V; Greiner, Dale L et al. (2014) Generation of improved humanized mouse models for human infectious diseases. J Immunol Methods 410:3-17
Luzuriaga, Katherine; Tabak, Barbara; Garber, Manuel et al. (2014) HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatment. J Infect Dis 210:1529-38
Usami, Yoshiko; Göttlinger, Heinrich (2013) HIV-1 Nef responsiveness is determined by Env variable regions involved in trimer association and correlates with neutralization sensitivity. Cell Rep 5:802-12

Showing the most recent 10 out of 122 publications