Abstract

Knowledge of the three-dimensional structure of biologically relevant molecules is having increasing impact in biology and medicine, and particularly in AIDS research. X-ray crystallography has been an especially important method for determining these structures, and computational biology has been very important for visualizing and interpreting these structures. Much of structural biology has been restricted to experts working in these areas. we propose in the Structural Biology core to establish a resource that will broaden the availability of these powerful tools to other researchers within the CR-CFAR. The core will provide assistance with protein production, purification, and crystallography, as well as with computer modeling of structures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
1P30AI042848-01
Application #
6100209
Study Section
Project Start
1998-09-01
Project End
1999-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Aaron Diamond AIDS Research Center
Department
Type
DUNS #
786658872
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Mukhopadhyay, Madhura; Galperin, Moran; Patgaonkar, Mandar et al. (2017) DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers. J Immunol 199:3437-3452
Collins, Pamela Y; Kondos, Leeza; Pillai, Aravind et al. (2016) Passive Suicidal Ideation and Community Mental Health Resources in South Africa. Community Ment Health J 52:541-50
Markowitz, Martin; Evering, Teresa H; Garmon, Donald et al. (2014) A randomized open-label study of 3- versus 5-drug combination antiretroviral therapy in newly HIV-1-infected individuals. J Acquir Immune Defic Syndr 66:140-7
Mantell, Joanne E; West, Brooke S; Sue, Kimberly et al. (2011) Health care providers: a missing link in understanding acceptability of the female condom. AIDS Educ Prev 23:65-77
Hoffman, Susie; Higgins, Jenny A; Beckford-Jarrett, Sharlene T et al. (2011) Contexts of risk and networks of protection: NYC West Indian immigrants' perceptions of migration and vulnerability to sexually transmitted diseases. Cult Health Sex 13:513-28
Zhukovsky, Mikhail A; Basmaciogullari, Stéphane; Pacheco, Beatriz et al. (2010) Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes. PLoS One 5:e13249
Coovadia, Hoosen; Mantell, Joanne E (2010) Adolescents and HIV in sub-Saharan Africa: a timely issue and missed opportunity. Clin Infect Dis 51:852-4
Flacher, Vincent; Tripp, Christoph H; Stoitzner, Patrizia et al. (2010) Epidermal Langerhans cells rapidly capture and present antigens from C-type lectin-targeting antibodies deposited in the dermis. J Invest Dermatol 130:755-62
Yuan, Wen; Li, Xing; Kasterka, Marta et al. (2009) Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies. AIDS Res Hum Retroviruses 25:319-28
Kassa, Aemro; Madani, Navid; Schön, Arne et al. (2009) Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain. J Virol 83:8364-78

Showing the most recent 10 out of 103 publications