Abstract

The overall objective of the Virology Core is to provide comprehensive virologic services, reagents, and biosafety level 3 facilities to members of the Columbia Rockefeller Center for AIDS Research, thereby facilitating their research on HIV/SIV, broadening the scope of their investigation, and promoting meaningful collaborations. Major core services will include HIV/SIV isolation, propagation and titration; 2) viral quantification by culture, bDNA amplification, PCR and RT-PCR; 3) characterization of viral phenotype with respect to growth kinetics, syncytium-inducing capacity, cellular tropism, and co-receptor usage; 4) analysis of HIV/SIV genotype; 5) phenotype and genotypic characterization of drug resistance; and 6) determination of host cell susceptibility to HIV and co-receptor expression. The core will also provide valuable reagents and cell lines to CFAR members, as well as the use of biosafety level 3 space. These services and the overall virologic expertise in the Core should enhance the research activities of the CR-CFAR.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
7P30AI042848-03
Application #
6340716
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
2000
Total Cost
$195,664
Indirect Cost

  Institution

Name
Aaron Diamond AIDS Research Center
Department
Type
DUNS #
786658872
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Mukhopadhyay, Madhura; Galperin, Moran; Patgaonkar, Mandar et al. (2017) DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers. J Immunol 199:3437-3452
Collins, Pamela Y; Kondos, Leeza; Pillai, Aravind et al. (2016) Passive Suicidal Ideation and Community Mental Health Resources in South Africa. Community Ment Health J 52:541-50
Markowitz, Martin; Evering, Teresa H; Garmon, Donald et al. (2014) A randomized open-label study of 3- versus 5-drug combination antiretroviral therapy in newly HIV-1-infected individuals. J Acquir Immune Defic Syndr 66:140-7
Mantell, Joanne E; West, Brooke S; Sue, Kimberly et al. (2011) Health care providers: a missing link in understanding acceptability of the female condom. AIDS Educ Prev 23:65-77
Hoffman, Susie; Higgins, Jenny A; Beckford-Jarrett, Sharlene T et al. (2011) Contexts of risk and networks of protection: NYC West Indian immigrants' perceptions of migration and vulnerability to sexually transmitted diseases. Cult Health Sex 13:513-28
Zhukovsky, Mikhail A; Basmaciogullari, Stéphane; Pacheco, Beatriz et al. (2010) Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes. PLoS One 5:e13249
Coovadia, Hoosen; Mantell, Joanne E (2010) Adolescents and HIV in sub-Saharan Africa: a timely issue and missed opportunity. Clin Infect Dis 51:852-4
Flacher, Vincent; Tripp, Christoph H; Stoitzner, Patrizia et al. (2010) Epidermal Langerhans cells rapidly capture and present antigens from C-type lectin-targeting antibodies deposited in the dermis. J Invest Dermatol 130:755-62
Yuan, Wen; Li, Xing; Kasterka, Marta et al. (2009) Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies. AIDS Res Hum Retroviruses 25:319-28
Kassa, Aemro; Madani, Navid; Schön, Arne et al. (2009) Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain. J Virol 83:8364-78

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