Core E: Women and AIDS Core (Clinical Research Core) Staff of the core will include Core Director Timothy P. Flanigan, M.D. He is Associate Professor of Medicine at Brown University School of Medicine and Director of the Women's Immunology Center and the Division of Clinical Immunology at the Mariam Hospital. Dr. Flanigan will provide oversight of the core laboratory, including supervision of the gynecological nurse, convene meetings of the active core users on a periodic basis, and serve on the Executive Committee of the CFAR. Joan Gormley, R.N., a nurse in the Miriam Women's Immunology Center at the Miriam Hospital, will serve as the gynecological nurse for the core, obtaining study specimens according to protocols developed by investigators there. Basic purposes of the core will be to support basic and clinical research focusing on HIV treatment, progression and complications in women. The core is centered around the CDC-funded HIV Epidemiology Research Study (HERS) cohort (Charles Carpenter, PI) and will offer 1) gynecological specimen collection for viral quantification, evaluation of immunologically-active cells and markers, and secretory antibody quantification; 2) coordination of the HERS cohort for translational research investigation; and 3) sample repository of HERS cohort specimens for research purposes. Key scientific studies to be supported by this core include studies currently based on the HERS study: Dr. Timothy Flanigan's research on genital mucosal immunity Dr. Susan Cu-Uvin's study of the effect of anti- retroviral therapy on viral load in the female genital tract, and Dr. Ken Mayers research on effect of genitourinary inflammation on viral load. The core will also support new research by Dr. Sherwood Gorbach into the nutritional impact of highly-active anti-retroviral therapy (HAART) and an interventional trial involving anabolic training to promote lean muscle mass gain in patients receiving HAART. The core will also support outcomes analysis of the HERS cohort in conjunction with other clinical cohorts to be performed by Dr. Ira Wilson.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI042853-04
Application #
6496643
Study Section
Project Start
2001-09-01
Project End
2002-08-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Miriam Hospital
Department
Type
DUNS #
039318308
City
Providence
State
RI
Country
United States
Zip Code
02906
Skeer, Margie R; Ladin, Keren; Wilkins, Lindsay E et al. (2018) 'Hep C's like the common cold': understanding barriers along the HCV care continuum among young people who inject drugs. Drug Alcohol Depend 190:246-254
Ma, Y; Horsburgh, C R; White, L F et al. (2018) Quantifying TB transmission: a systematic review of reproduction number and serial interval estimates for tuberculosis. Epidemiol Infect 146:1478-1494
Wurcel, Alysse G; Burke, Deirdre; Skeer, Margie et al. (2018) Sex work, injection drug use, and abscesses: Associations in women, but not men. Drug Alcohol Depend 185:293-297
Dompreh, Albert; Tang, Xiaoli; Zhou, Jianlin et al. (2018) Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis. Antimicrob Agents Chemother 62:
Schackman, Bruce R; Gutkind, Sarah; Morgan, Jake R et al. (2018) Cost-effectiveness of hepatitis C screening and treatment linkage intervention in US methadone maintenance treatment programs. Drug Alcohol Depend 185:411-420
Adams, Joƫlla W; Bryant, Kendall J; Edelman, Jennifer E et al. (2018) Association of Cannabis, Stimulant, and Alcohol use with Mortality Prognosis Among HIV-Infected Men. AIDS Behav 22:1341-1351
Krieger, Maxwell S; Yedinak, Jesse L; Buxton, Jane A et al. (2018) High willingness to use rapid fentanyl test strips among young adults who use drugs. Harm Reduct J 15:7
Bazazi, Alexander R; Vijay, Aishwarya; Crawford, Forrest W et al. (2018) HIV Testing and awareness of HIV status among people who inject drugs in greater Kuala Lumpur, Malaysia. AIDS Care 30:59-64
van den Berg, Jacob J; Javanbakht, Marjan; Gorbach, Pamina M et al. (2018) Partner Notification for Youth Living With HIV in 14 Cities in the United States. J Acquir Immune Defic Syndr 77:46-52
Hu, Liangyuan; Hogan, Joseph W; Mwangi, Ann W et al. (2018) Modeling the causal effect of treatment initiation time on survival: Application to HIV/TB co-infection. Biometrics 74:703-713

Showing the most recent 10 out of 806 publications