Core I: Translational ScienceThe Translational Science Core was established in 2002. The intent of this core is to facilitate thedevelopment and implementation of novel clinical/translational HIV studies by CFAR investigators at Tuftsand Brown as well as at international sites. The core responds to the evolution of the CFAR epidemic into anever more complex syndrome which requires expansion of basic and clinical research to translational studiesthat are capable of examining the clinical import of basic research and identifying the basic mechanisms forobservations made in clinical studies. Funding of the core has permitted the development of interdisciplinarystudies that would not otherwise be supported and has recruited excellent new investigators to initiate HIVrelated research projects. The services provided by this core are diverse and have led to the development ofa diverse group of studies.The primary aims of the core are to:1. Specifically support the investigation of the role of human immunodeficiency virus infection (viralburden, viral type and inflammatory changes induced by the viral infection) on clinical outcomesincluding development of resistance, and development of metabolic and body shape changes (HIVassociatedlipodystrophy).2. Support translational studies of complications of HIV and its therapies, including tuberculosis,diarrheal disease such as cryptosporidal infection and antiretroviral drug toxicities.3. Support of translational studies in developing the infrastructure and expertise necessary to conductthese complex studies, to be defined as needed by the site and the investigator.PERFORMANCE SITE(S) (organization, city, state)Tufts University, Boston, MAPHS 398 (Rev. 04/06) Page 377 Form Page 2
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