The CFAR Molecular Core will provide CFAR investigators with the molecular biological regents and tools necessary to pursue their research by serving as a repository for expression vectors, antibodies and antisera, cell lines, and viral vectors. In addition to its role as a reagent repository, the Molecular Core will provide advice and expertise to investigators on such topics as the cloning and manipulation of genes and the functional analysis of viral proteins such as Env. Importantly, the Molecular Core will interface closely with the Virology Core. Viral genes will be isolated from primary viruses that are of interest to CFAR investigators and that are provided by the Virology Core, and placed into appropriate vectors. High level expression vectors will then be provided, when requested, to the Structural Core for large-scale production of gene products. The Molecular Core will also interact directly with the Clinical Core by genotyping patient samples for polymorphisms associated with altered disease progression. Thus, by consolidating and making available important reagents, by providing technical advance, by genotyping patient samples, and though the construction of expression systems the Molecular Core will facilitate interactions between the Virology, Clinical, and Structural Cores and will assist investigators in their research efforts. In addition, the Molecular Core will help foster collaborations and help draw new and established investigators into HIV/SIV research.
| Sherrill-Mix, Scott; McCormick, Kevin; Lauder, Abigail et al. (2018) Allometry and Ecology of the Bilaterian Gut Microbiome. MBio 9: |
| Crits-Christoph, Paul; Gallop, Robert; Noll, Elizabeth et al. (2018) Impact of a medical home model on costs and utilization among comorbid HIV-positive Medicaid patients. Am J Manag Care 24:368-375 |
| Kadimisetty, Karteek; Song, Jinzhao; Doto, Aoife M et al. (2018) Fully 3D printed integrated reactor array for point-of-care molecular diagnostics. Biosens Bioelectron 109:156-163 |
| Li, Binglan; Verma, Shefali S; Veturi, Yogasudha C et al. (2018) Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression. Pac Symp Biocomput 23:448-459 |
| Fraietta, Joseph A; Nobles, Christopher L; Sammons, Morgan A et al. (2018) Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells. Nature 558:307-312 |
| Kelly, Matthew S; Surette, Michael G; Smieja, Marek et al. (2018) Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana. Pediatr Infect Dis J 37:1176-1183 |
| Chitre, Avantika S; Kattah, Michael G; Rosli, Yenny Y et al. (2018) A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog 14:e1006806 |
| Milligan, Michael G; Bigger, Elizabeth; Abramson, Jeremy S et al. (2018) Impact of HIV Infection on the Clinical Presentation and Survival of Non-Hodgkin Lymphoma: A Prospective Observational Study From Botswana. J Glob Oncol :1-11 |
| Medvec, Andrew R; Ecker, Christopher; Kong, Hong et al. (2018) Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium. Mol Ther Methods Clin Dev 8:65-74 |
| Washio, Yukiko; Novack Wright, Elizabeth; Davis-Vogel, Annet et al. (2018) Prior Exposure to Intimate Partner Violence Associated With Less HIV Testing Among Young Women. J Interpers Violence :886260518768564 |
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