This proposal represents a collaboration between the University of Pennsylvania, the Children's Hospital of Philadelphia and the Wistar Institute to establish a Center for AIDS research that would link the AIDS research communities at these three institutions within an administrative structure committed to fostering interdisciplinary AIDS research activities. The Penn-CFAR would be established as a distinct University Center whose members would be derived from multiple Schools, Departments and Institutes located on the Penn campus and whose Director would report directly to the Dean of the University of Penn. School of Medicine. The primary goals of the Penn-CFAR will be 1) to create an infrastructure that facilitates communication, collaboration and synergy among AIDS/HIV researchers; 2) to establish shared resource cores facilities that enhance the overall research environment for individual investigators and that promote interdisciplinary research activities; 3) to develop programs in community outreach and AIDS education for students and faculty, and 4) to stimulate the recruitment of new faculty that will help to develop clinical and basic science programs that are at the forefront of AIDS research. The Penn- CFAR will be organized around 5 research programs: HIV Pathogenesis, Structural Biology, Clinical/Therapeutics, Immunology/Vaccine and Behavioral and Social Sciences. The Center will be directed by Dr. James A. Hoxie with the assistance of a Co-Director (Dr. Francisco Gonzalez- Scarano) and an Executive Committee whose membership includes senior scientists from the 5 Penn-CFAR Programs (Drs. Linda Aiken, Irwin Chaiken, Robert Doms, Harvey Friedman, Michael Malim, Stuart Starr, Peter Traber and James Wilson). In year 1 this CFAR will support an Administrative Core, a Developmental core, and 7 shared resource cores including Clinical/Therapeutics, Virus/Primary Cell, Molecular, Structural Biology, Immunology, Behavioral and Social Sciences, and Biostatistics and Data Management. The Center will be committed to developing a creative, comprehensive, and interdisciplinary AIDS research program that is fully integrated into the research and educational mission of the University and that will become the focal point for a continuing commitment at Penn, CHOP and Wister to meet the challenges posed by the AIDS pandemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI045008-05
Application #
6632071
Study Section
Special Emphasis Panel (ZAI1-EWS-A (J1))
Program Officer
Young, Janet M
Project Start
1999-07-01
Project End
2004-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
5
Fiscal Year
2003
Total Cost
$1,425,153
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Krump, Nathan A; Liu, Wei; You, Jianxin (2018) Mechanisms of persistence by small DNA tumor viruses. Curr Opin Virol 32:71-79
Gowda, Charitha; Lott, Stephen; Grigorian, Matthew et al. (2018) Absolute Insurer Denial of Direct-Acting Antiviral Therapy for Hepatitis C: A National Specialty Pharmacy Cohort Study. Open Forum Infect Dis 5:ofy076
Clarke, Erik L; Connell, A Jesse; Six, Emmanuelle et al. (2018) T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency. Genome Med 10:70
Coviello, D M; Lovato, R; Apostol, K et al. (2018) Prevalence of HIV Viral Load Suppression Among Psychiatric Inpatients with Comorbid Substance Use Disorders. Community Ment Health J :
Martei, Yehoda M; Pace, Lydia E; Brock, Jane E et al. (2018) Breast Cancer in Low- and Middle-Income Countries: Why We Need Pathology Capability to Solve This Challenge. Clin Lab Med 38:161-173
Ojikutu, Bisola O; Bogart, Laura M; Higgins-Biddle, Molly et al. (2018) Facilitators and Barriers to Pre-Exposure Prophylaxis (PrEP) Use Among Black Individuals in the United States: Results from the National Survey on HIV in the Black Community (NSHBC). AIDS Behav 22:3576-3587
Martin, Maureen P; Naranbhai, Vivek; Shea, Patrick R et al. (2018) Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest 128:1903-1912
Wood, Sarah; Ratcliffe, Sarah; Gowda, Charitha et al. (2018) Impact of insurance coverage on HIV transmission potential among antiretroviral therapy-treated youth living with HIV. AIDS 32:895-902
Shin, S S; Modongo, C; Zetola, N M et al. (2018) High rates of exposure to tuberculosis patients among HIV-infected health care workers in Botswana. Int J Tuberc Lung Dis 22:366-370
Genn, Leah; Chapman, Jennifer; Okatch, Harriet et al. (2018) Pharmacy Refill Data are Poor Predictors of Virologic Treatment Outcomes in Adolescents with HIV in Botswana. AIDS Behav :

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