The activities of the International Core (Core I) are centered in Botswana, a country that serves as a remarkable success story for confronting the HIV/AIDS epidemic in sub-Saharan Africa. Core I has made impressive advances in performing HIV/AIDS research that is relevant to the people of Botswana and that has advanced knowledge of the global epidemic. Markers of our accomplishments include the large number of NIH and Foundation grants in HIV/AIDS that Core I investigators have secured for their research in Botswana during the current funding cycle, the substantial growth in number and quality of publications, and the success at attaining national and international recognition for their research by junior faculty located at Penn and by junior faculty who are residing fulltime in Botswana as part of the Botswana-UPenn Partnership (BUP) program (an extension of Penn's campus in Botswana). The BUP has robust clinical and educational programs focused on providing care and technical assistance related to HIV and its complications, HIV-TB co-infection, multidrug resistant TB, cervical cancer screening in HIV infected women using the

Public Health Relevance

The Penn CFAR International Core has developed vibrant and highly productive research programs in collaboration with the Government of Botswana and the University of Botswana School of Medicine. The research focuses on HIV and its complications, tuberculosis, screening for cervical cancer in HIV infected women, and use of cell phones to improve health care delivery. The impact is substantial as Penn scientists partner with researchers in country to address some ofthe most pressing issues ofthe HIV/AIDS epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI045008-17
Application #
8847273
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
17
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Shin, S S; Modongo, C; Zetola, N M et al. (2018) High rates of exposure to tuberculosis patients among HIV-infected health care workers in Botswana. Int J Tuberc Lung Dis 22:366-370
Genn, Leah; Chapman, Jennifer; Okatch, Harriet et al. (2018) Pharmacy Refill Data are Poor Predictors of Virologic Treatment Outcomes in Adolescents with HIV in Botswana. AIDS Behav :
Goldberg, Drew W; Tenforde, Mark W; Mitchell, Hannah K et al. (2018) Neurological Sequelae of Adult Meningitis in Africa: A Systematic Literature Review. Open Forum Infect Dis 5:ofx246
Abbas, Arwa A; Young, Jacque C; Clarke, Erik L et al. (2018) Bidirectional transfer of Anelloviridae lineages between graft and host during lung transplantation. Am J Transplant :
Haas, David W; Bradford, Yuki; Verma, Anurag et al. (2018) Brain neurotransmitter transporter/receptor genomics and efavirenz central nervous system adverse events. Pharmacogenet Genomics 28:179-187
Papasavvas, Emmanouil; Lada, Steven M; Joseph, Jocelin et al. (2018) Analytical ART interruption does not irreversibly change pre-interruption levels of cellular HIV. AIDS :
Brocca-Cofano, Egidio; Xu, Cuiling; Wetzel, Katherine S et al. (2018) Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques. J Virol 92:
Bengsch, Bertram; Ohtani, Takuya; Khan, Omar et al. (2018) Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity 48:1029-1045.e5
Page, Kathleen R; Grieb, Suzanne Dolwick; Nieves-Lugo, Karen et al. (2018) Enhanced immigration enforcement in the USA and the transnational continuity of HIV care for Latin American immigrants in deportation proceedings. Lancet HIV 5:e597-e604
Costea, Paul I; Hildebrand, Falk; Arumugam, Manimozhiyan et al. (2018) Enterotypes in the landscape of gut microbial community composition. Nat Microbiol 3:8-16

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