Under the direction of Dr. John D. Altman, the mission of Core H, the Emory CFAR Immunology CoreLaboratory (ICL), is to provide the Emory community with the highest quality assessments of immunologicalfunction necessary for the study of the pathogenesis, treatment, and prevention of immunodeficiency virusinfections in humans and non-human primates. The ICL will achieve this mission through the followingSpecific Aims:1. Develop and perform optimized, standardized, and validated assays of cellular immune function invaccinated subjects, in HIV-infected humans, and in SIV-infected non-human primates (NHP);2. Create a repository of cryopreserved PBMC from naive (off-study) monkeys from the YerkesPrimate Research Center, thereby providing CFAR investigators with access to esse'ntial negative controlsamples for assay development and validation.3. Achieve economies of scale through the provision of immunological reagent resources shared bymultiple independent laboratories;4. Maintain a CFAR Flow Cytometry Core, for the purpose of providing members of the Emory CFAR, andthe larger AIDS research community, with the highest quality flow cytometry data and cell sortingservices available, including handling of biohazardous samples;5. Promote immunological assay education and training opportunities for CFAR investigators, theAIDS research community in Atlanta, and national and international AIDS investigators.Through these Aims, the ICL will enable all Emory CFAR investigators to take advantage of innovative andpowerful modern approaches to quantitative analysis of innate and acquired humoral and cell-mediatedimmunity that have been developed by individual Emory investigators and scientists elsewhere. Accuratecharacterization of cell-mediated immune responses is essential for guiding preclinical vaccine development,for determining possible correlates of vaccine efficacy in preclinical and clinical trials, and for betterunderstanding AIDS pathogenesis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI050409-10
Application #
7667903
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2008-08-01
Project End
2012-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
10
Fiscal Year
2008
Total Cost
$380,685
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Moody, Raymond L; Starks, Tyrel J; Grov, Christian et al. (2018) Internalized Homophobia and Drug Use in a National Cohort of Gay and Bisexual Men: Examining Depression, Sexual Anxiety, and Gay Community Attachment as Mediating Factors. Arch Sex Behav 47:1133-1144
Woodson, Evonne; Goldberg, Alec; Michelo, Clive et al. (2018) HIV transmission in discordant couples in Africa in the context of antiretroviral therapy availability. AIDS 32:1613-1623
Bratcher, Anna; Schlueter Wirtz, Susan; Siegler, Aaron J (2018) Users of a National Directory of PrEP Service Providers: Beliefs, Self-Efficacy, and Progress Toward Prescription. J Acquir Immune Defic Syndr 78:e28-e30
Anderson, Albert M; Easley, Kirk A; Kasher, Nicole et al. (2018) Neurofilament light chain in blood is negatively associated with neuropsychological performance in HIV-infected adults and declines with initiation of antiretroviral therapy. J Neurovirol 24:695-701
Carnathan, Diane; Lawson, Benton; Yu, Joana et al. (2018) Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques. J Virol 92:
Adekambi, Toidi; Ibegbu, Chris C; Cagle, Stephanie et al. (2018) High Frequencies of Caspase-3 Expressing Mycobacterium tuberculosis-Specific CD4+ T Cells Are Associated With Active Tuberculosis. Front Immunol 9:1481
Ende, Zachary; Deymier, Martin J; Claiborne, Daniel T et al. (2018) HLA Class I Downregulation by HIV-1 Variants from Subtype C Transmission Pairs. J Virol :
Eckard, Allison Ross; O'Riordan, Mary Ann; Rosebush, Julia C et al. (2018) Vitamin D supplementation decreases immune activation and exhaustion in HIV-1-infected youth. Antivir Ther 23:315-324
Haddad, Lisa B; Wall, Kristin M; Kilembe, William et al. (2018) Bacterial vaginosis modifies the association between hormonal contraception and HIV acquisition. AIDS 32:595-604
Patel, Viraj V; Dange, Alpana; Rawat, Shruta et al. (2018) Barriers to HIV Testing Among Men Who Have Sex With Men in India Reached Online: Implications for Interventions. J Acquir Immune Defic Syndr 78:e30-e34

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