We are proposing to develop an Immunology Core Laboratory within the UNC CFAR. The goal of the proposed Core will be to facilitate research within the UNC CFAR community including investigators at UNC Chapel Hill, Family Health International (FHI), Research Triangle Institute (RTI) and affiliated international investigators. This goal will be accomplished by the provision of: (1) a wide variety of laboratory services including specimen processing/storage/shipping, assessment of soluble mediators and antibodies, and assessment of phenotypic and functional parameters of the immune system;some of these services will be provided in collaboration with other investigators within and outside of UNC that offer specialized expertise and/or instrumentation not physically available within the core;(2) training in immunologic techniques to domestic and international investigators and their trainees;(3) consultation on the design and implementation of immunologic assays in HIV related studies;(4) management (collection, tracking, storage and provision) of plasma and whole blood cell pellet repositories;(5) acquisition, manipulation and provision of blood and/or blood components to basic investigators to facilitate basic science investigations of pathogenesis of and immune responses to HIV infection. The Core services provided will make a positive contribution to the UNC CFAR by extending the expertise previously available in the UNC ACTG-ISL to the entire CFAR membership as well as providing/facilitating access to new technologies, so as to promote basic, translational and clinical research at UNC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI050410-13
Application #
8080834
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
13
Fiscal Year
2010
Total Cost
$228,457
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Evon, Donna M; Stewart, Paul W; Amador, Jipcy et al. (2018) A comprehensive assessment of patient reported symptom burden, medical comorbidities, and functional well being in patients initiating direct acting antiviral therapy for chronic hepatitis C: Results from a large US multi-center observational study. PLoS One 13:e0196908
Gausi, Blessings; Chagomerana, Maganizo B; Tang, Jennifer H et al. (2018) Human Immunodeficiency Virus Serodiscordance and Dual Contraceptive Method Use Among Human Immunodeficiency Virus-infected Men and Women in Lilongwe, Malawi. Sex Transm Dis 45:747-753
Kalayjian, Robert C; Albert, Jeffrey M; Cremers, Serge et al. (2018) Women have enhanced bone loss associated with phosphaturia and CD4+ cell restoration during initial antiretroviral therapy. AIDS 32:2517-2524
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Cheng, Weibin; Xu, Huifang; Zhong, Fei et al. (2018) Can HIV service data be used for surveillance purposes?: a case study in Guangzhou, China. BMC Public Health 18:1268
Gradissimo, Ana; Lam, Jessica; Attonito, John D et al. (2018) Methylation of High-Risk Human Papillomavirus Genomes Are Associated with Cervical Precancer in HIV-Positive Women. Cancer Epidemiol Biomarkers Prev 27:1407-1415
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Price, Joan T; Mollan, Katie R; Fuseini, Nurain M et al. (2018) Vaginal progesterone to reduce preterm birth among HIV-infected pregnant women in Zambia: a feasibility study protocol. Pilot Feasibility Stud 4:21
Davy-Mendez, Thibaut; Napravnik, Sonia; Zakharova, Oksana et al. (2018) Acute HIV Infection and CD4/CD8 Ratio Normalization After Antiretroviral Therapy Initiation. J Acquir Immune Defic Syndr 79:510-518
Cole, Stephen R; Edwards, Jessie K; Westreich, Daniel et al. (2018) Estimating multiple time-fixed treatment effects using a semi-Bayes semiparametric marginal structural Cox proportional hazards regression model. Biom J 60:100-114

Showing the most recent 10 out of 1688 publications