The long term goals of the Developmental Core are to solicit and provide funding for novel research projects focusing on HIV from our three member institutions (FHl, RTI, UNC) as well as Historically Black Colleges and Universities (HBCUs) throughout North Carolina and international partners working with UNC, RTI, and FHl. We will conduct objective peer review and assign senior investigators as mentors to nurture the research and subsequent publication and grant submission. In the first year ofthe new grant cycle we will combine $150,000 of CFAR funds with $75,000 of UNC funds to support small ($5,000-$20,000) awards in all aspects of HIV research (basic and clinical sciences, translational research, epidemiology, vaccinology, and behavioral research). Promising minority, female and junior investigators will be identified and mentored until they have successful independent careers, including external funding. We will continue to focus on the ongoing epidemic in women, minorities and international communities. We will also make larger awards (up to $50,000) in two settings: collaborative multidisciplinary efforts that originate in one of the Working Groups, which include the four CFAR initiatives;and in collaboration with the Developmental Core of the CTSA in which the larger award is made but the costs are shared with the CFAR and in some cases also the sponsoring Department, thus leveraging CFAR funding 2-4 fold. Outreach and education will be accomplished through: 1) presentation by all awardees at our weekly ID/CFAR conference, 2) our annual HIV Update course for 500 clinicians from the Southeast, 3) presentation of posters by awardees at the HIV Update and World AIDS Day, and 4) Research Dissemination Meetings in South Africa and Malawi. Continuous quality improvement will remain a focus consisting of a review of the entire process including solicitation, review, mentoring and productivity of awardees.

Public Health Relevance

The Developmental Core provides funding to support new research and new researchers in the context of a large supportive research environment. These small awards impact research both domestically and internationally. The goal of this core is encourage a dynamic and risk-taking research environment that can lead to new lines of research with the long term goal of impacting the HIV epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI050410-14
Application #
8329973
Study Section
Special Emphasis Panel (ZAI1-ELB-A (J1))
Project Start
2011-08-01
Project End
2016-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
14
Fiscal Year
2011
Total Cost
$302,367
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Gausi, Blessings; Chagomerana, Maganizo B; Tang, Jennifer H et al. (2018) Human Immunodeficiency Virus Serodiscordance and Dual Contraceptive Method Use Among Human Immunodeficiency Virus-infected Men and Women in Lilongwe, Malawi. Sex Transm Dis 45:747-753
Muessig, Kathryn E; Knudtson, Kelly A; Soni, Karina et al. (2018) ""I DIDN'T TELL YOU SOONER BECAUSE I DIDN'T KNOW HOW TO HANDLE IT MYSELF."" DEVELOPING A VIRTUAL REALITY PROGRAM TO SUPPORT HIV-STATUS DISCLOSURE DECISIONS. Digit Cult Educ 10:22-48
Adimora, Adaora A; Ramirez, Catalina; Benning, Lorie et al. (2018) Cohort Profile: The Women's Interagency HIV Study (WIHS). Int J Epidemiol 47:393-394i
Gradissimo, Ana; Lam, Jessica; Attonito, John D et al. (2018) Methylation of High-Risk Human Papillomavirus Genomes Are Associated with Cervical Precancer in HIV-Positive Women. Cancer Epidemiol Biomarkers Prev 27:1407-1415
Ong, Jason J; Wei, Chongyi; Pan, Stephen et al. (2018) Individuals have the right to avoid sex with partners unwilling to test for HIV but do not have a right to force them to test for HIV. J Acquir Immune Defic Syndr :
Hightow-Weidman, Lisa B; Muessig, Kathryn; Rosenberg, Eli et al. (2018) University of North Carolina/Emory Center for Innovative Technology (iTech) for Addressing the HIV Epidemic Among Adolescents and Young Adults in the United States: Protocol and Rationale for Center Development. JMIR Res Protoc 7:e10365
Cole, Stephen R; Edwards, Jessie K; Westreich, Daniel et al. (2018) Estimating multiple time-fixed treatment effects using a semi-Bayes semiparametric marginal structural Cox proportional hazards regression model. Biom J 60:100-114
Henderson, Gail E; Peay, Holly L; Kroon, Eugene et al. (2018) Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment. J Med Ethics 44:270-276
Honeycutt, Jenna B; Liao, Baolin; Nixon, Christopher C et al. (2018) T cells establish and maintain CNS viral infection in HIV-infected humanized mice. J Clin Invest 128:2862-2876
Rosenberg, Nora E; Bhushan, Nivedita L; Vansia, Dhrutika et al. (2018) Comparing Youth-Friendly Health Services to the Standard of Care Through ""Girl Power-Malawi"": A Quasi-Experimental Cohort Study. J Acquir Immune Defic Syndr 79:458-466

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