The goals of the Virology, Immunology &Microbiology (VIM) Core are to enhance the research capacity of the UNC CFAR research community by providing access to state of-the-art tools research, and for diagnosis and monitoring HIV-1-positive patients in clinical trials. The VIM Core also provides leadership to promote HIVIAIDS research through collaboration, training, and mentoring.
The specific aims are to 1) provide quality virologic, immunologic and microbiologic assays and services, 2) provide training and mentorship to the domestic and international CFAR community and build capacity at international sites, 3) provide leadership through activities locally, nationally, and internationally, 4) support NIH networks and CFAR-CFAR collaborations by participating in WIHS, HPTN, IMPAACT, and ACTG, 5) support new CFAR initiatives through collaborations with UNC CFAR members, and 6) engage in evaluation and strategic planning, using input from user surveys, an Internal Advisory Board, and the CFAR External Advisory Board. Through these activities, the Virology, Immunology &Microbiology Core will provide key infrastructure support for the HIVIAIDS and HIV coinfection research activity of the CFAR membership. These activities will have a significant impact on the future of the epidemic by providing assays for HIV-1 and other sexually transmitted infections (including ultra-low copy number and POC HIV-1 assays and nucleic acid amplification testing for non-HIV STis), biospecimen procurement and distribution, immune phenotype, function and immunogenetic testing, training and mentoring new US and international scientists, and providing leadership locally, nationally, and globally.

Public Health Relevance

The CFAR is committed to supporting research in treatment, prevention, epidemiology, and pathogenesis as part of an overall effort to change the course of the HIV epidemic both domestically and in the international setting. The CFAR provides infrastructure support for our membership, and leadership both within the membership and within the institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI050410-17
Application #
8918807
Study Section
Special Emphasis Panel (ZAI1-ELB-A (J1))
Program Officer
Namkung, Ann S
Project Start
2014-08-01
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
17
Fiscal Year
2014
Total Cost
$347,942
Indirect Cost
$105,258
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Muessig, Kathryn E; Knudtson, Kelly A; Soni, Karina et al. (2018) ""I DIDN'T TELL YOU SOONER BECAUSE I DIDN'T KNOW HOW TO HANDLE IT MYSELF."" DEVELOPING A VIRTUAL REALITY PROGRAM TO SUPPORT HIV-STATUS DISCLOSURE DECISIONS. Digit Cult Educ 10:22-48
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Hightow-Weidman, Lisa B; Muessig, Kathryn; Rosenberg, Eli et al. (2018) University of North Carolina/Emory Center for Innovative Technology (iTech) for Addressing the HIV Epidemic Among Adolescents and Young Adults in the United States: Protocol and Rationale for Center Development. JMIR Res Protoc 7:e10365
Cole, Stephen R; Edwards, Jessie K; Westreich, Daniel et al. (2018) Estimating multiple time-fixed treatment effects using a semi-Bayes semiparametric marginal structural Cox proportional hazards regression model. Biom J 60:100-114
Henderson, Gail E; Peay, Holly L; Kroon, Eugene et al. (2018) Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment. J Med Ethics 44:270-276
Honeycutt, Jenna B; Liao, Baolin; Nixon, Christopher C et al. (2018) T cells establish and maintain CNS viral infection in HIV-infected humanized mice. J Clin Invest 128:2862-2876
Rosenberg, Nora E; Bhushan, Nivedita L; Vansia, Dhrutika et al. (2018) Comparing Youth-Friendly Health Services to the Standard of Care Through ""Girl Power-Malawi"": A Quasi-Experimental Cohort Study. J Acquir Immune Defic Syndr 79:458-466

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