This application proposes continued funding of the Harvard University Center for AIDS Research (HU CFAR). HU CFAR is the umbrella organization for AIDS research at Harvard, operating out of the Provost's Office. It represents each of the Harvard affiliated schools as well as the affiliated hospitals, including Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Massachusetts General Hospital, Brigham & Women's Hospital. In addition, it includes the Lemuel Shattuck Hospital and Fenway Health, extending its reach to additional clinical populations and translational research sites outside Harvard. HU CFAR builds collaborations and provides infrastructure support to coordinate and promote emerging opportunities in basic, clinical, behavioral, and translational HIV research. Research emphasis among investigators includes studies of molecular virology, pathogenesis, host immune responses, epidemiology, treatment, vaccines and prevention. CFAR also oversees 3 Scientific Programs (Epidemiology and Implementation Science, International, and HIV Vaccines) as well as 3 Scientific Working Groups (HIV Eradication, TB-HIV Co-infection and Health Equity). Six Core facilities have also been identified for HU CFAR support: Clinical, Biostatistics and Bioinformatics, Humanized Mouse, Advanced Technologies, Behavioral and Social Sciences and Biosafety Level 3. In addition, an Administrative Core will provide strategic planning and fiscal oversight, and a Developmental Core will support innovative pilot projects related to the goals of the scientific programs and scientific working groups. Undertaking the following specific aims, the HU CFAR will continue to expand, promote, and facilitate collaborative, multidisciplinary activities in AID research among CFAR members as the Harvard University model for collaborative inter-institutional interactions:
Aim 1 : to facilitate and expand synergistic multidisciplinary collaborations among the diverse and highly successful HU-affiliated HIV/AIDS researchers and their trainees, Aim 2; to promote new interactions and support innovative research initiatives capable of more effectively addressing key HIV/AIDS related research questions aimed at bringing an end to the epidemic, Aim 3: to attract, engage, support and mentor the next generation of early career scientists into HIV/AIDS research.

Public Health Relevance

The HU CFAR is a comprehensive Center providing the infrastructure to integrate Harvard University's multidisciplinary AIDS-related clinical and basic research programs. This provides a unique platform to maximize the contribution to public health by Harvard's HIV/AIDS investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI060354-14
Application #
9317407
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Namkung, Ann S
Project Start
2004-07-01
Project End
2019-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
14
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Organized Research Units
DUNS #
082359691
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Draz, Mohamed Shehata; Venkataramani, Manasa; Lakshminarayanan, Harini et al. (2018) Nanoparticle-enhanced electrical detection of Zika virus on paper microchips. Nanoscale 10:11841-11849
Muiru, Anthony N; Bibangambah, Prossy; Hemphill, Linda et al. (2018) Distribution and Performance of Cardiovascular Risk Scores in a Mixed Population of HIV-Infected and Community-Based HIV-Uninfected Individuals in Uganda. J Acquir Immune Defic Syndr 78:458-464
Dale, Sannisha K; Pierre-Louis, Catherine; Bogart, Laura M et al. (2018) Still I rise: The need for self-validation and self-care in the midst of adversities faced by Black women with HIV. Cultur Divers Ethnic Minor Psychol 24:15-25
Blass, Eryn; Aid, Malika; Martinot, Amanda J et al. (2018) Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection. J Virol 92:
Dale, Sannisha K; Safren, Steven A (2018) Striving Towards Empowerment and Medication Adherence (STEP-AD): A Tailored Cognitive Behavioral Treatment Approach for Black Women Living With HIV. Cogn Behav Pract 25:361-376
Addison, Daniel; Lawler, Patrick R; Emami, Hamed et al. (2018) Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer. J Stroke 20:71-79
Ojikutu, B O; Nnaji, C; Sithole-Berk, J et al. (2018) African born women living with HIV in the United States: unmet needs and opportunities for intervention. AIDS Care 30:1542-1550
Ojikutu, Bisola O; Bogart, Laura M; Higgins-Biddle, Molly et al. (2018) Facilitators and Barriers to Pre-Exposure Prophylaxis (PrEP) Use Among Black Individuals in the United States: Results from the National Survey on HIV in the Black Community (NSHBC). AIDS Behav 22:3576-3587
Martin-Gayo, Enrique; Cole, Michael B; Kolb, Kellie E et al. (2018) A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers. Genome Biol 19:10
Murray, Eleanor J; Robins, James M; Seage 3rd, George R et al. (2018) Using Observational Data to Calibrate Simulation Models. Med Decis Making 38:212-224

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