CoreD Core D Molecular Virology Core is comprised of an HIV/AIDS DNA sequence analysis component, a BSL-3 virology facility, and microRNA function/RNA interference technologies to serve the evolving needs of basic and clinical translational HIV and associated opportunistic infections research at Duke University.
The specific aims of the Molecular Virology Core are: 1. Provision of Core Services to facilitate the implementation of DNA sequencing, molecular virology assays, and state-of-the-art support for RNA interference and microRNA functional analyses in CFAR laboratories through shared resources in a cost efficient manner. 2. To provide expertise and core resources related to the role of specific human genes in the replication and pathogenesis of HIV-1, opportunistic infections or AIDS-associated malignancies. 3. To stimulate interdisciplinary collaborations between academia and industry to further improve the technology offered by the Core and to provide a solid resource on which collaborations can be fostered. 4. To provide education and training opportunities to CFAR scientists in existing and newly developed virologic methodologies. In order to achieve these aims, the Molecular Virology Core is A) committed to maintaining a high quality of reagents and data through multiple QA/QC procedures and B) establishing a virologic resource that is based on current and future scientific needs of CFAR investigators.

Public Health Relevance

By providing state-of-the-art technical and scientific support for HIV-1 research at Duke and in the wider Research Triangle community, the Molecular Virology Core provides important, and often essential, support for research into novel anti-HIV drugs and into potential HIV vaccine approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI064518-08
Application #
8379354
Study Section
Special Emphasis Panel (ZAI1-JBS-A)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
8
Fiscal Year
2012
Total Cost
$185,797
Indirect Cost
$82,041
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Tabb, Zachary J; Mmbaga, Blandina T; Gandhi, Monica et al. (2018) Antiretroviral drug concentrations in hair are associated with virologic outcomes among young people living with HIV in Tanzania. AIDS 32:1115-1123
Williams, Wilton B; Han, Qifeng; Haynes, Barton F (2018) Cross-reactivity of HIV vaccine responses and the microbiome. Curr Opin HIV AIDS 13:9-14
Cherenack, Emily M; Sikkema, Kathleen J; Watt, Melissa H et al. (2018) Avoidant Coping Mediates the Relationship Between Self-Efficacy for HIV Disclosure and Depression Symptoms Among Men Who Have Sex with Men Newly Diagnosed with HIV. AIDS Behav 22:3130-3140
Sikkema, Kathleen J; Mulawa, Marta I; Robertson, Corne et al. (2018) Improving AIDS Care After Trauma (ImpACT): Pilot Outcomes of a Coping intervention Among HIV-Infected Women with Sexual Trauma in South Africa. AIDS Behav 22:1039-1052
Blasi, Maria; Negri, Donatella; LaBranche, Celia et al. (2018) IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells. Commun Biol 1:134
Collins, Lauren F; Chan, Austin; Zheng, Jiayin et al. (2018) Direct-Acting Antivirals Improve Access to Care and Cure for Patients With HIV and Chronic HCV Infection. Open Forum Infect Dis 5:ofx264
Wills, Saintedym; Hwang, Kwan-Ki; Liu, Pinghuang et al. (2018) HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis. J Virol 92:
Watt, Melissa H; Knippler, Elizabeth T; Knettel, Brandon A et al. (2018) HIV Disclosure Among Pregnant Women Initiating ART in Cape Town, South Africa: Qualitative Perspectives During the Pregnancy and Postpartum Periods. AIDS Behav 22:3945-3956
Clement, Meredith E; Okeke, Nwora L; Munn, Terry et al. (2018) Partnerships Between a University-Affiliated Clinic and Community-Based Organizations to Reach Black Men Who Have Sex With Men for PrEP Care. J Acquir Immune Defic Syndr 77:e25-e27
Naggie, Susanna; Swiderska-Syn, Marzena; Choi, Steve et al. (2018) Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection. Open Forum Infect Dis 5:ofy138

Showing the most recent 10 out of 488 publications