? Biostatistics and Computational Biology Core (Core E) The principal mission of the Duke CFAR is to establish, enrich, and provide continued infrastructure support to an academic research environment that will effectively promote collaboration and coordination among the community of HIV/AIDS investigators at Duke. The Biostatistics and Computational Biology (BCB) Core supports this mission by providing quantitative consulting services in support of experimental design, development of manuscripts and improvement of grant proposals. The BCB Core enriches the academic research environment by providing mentoring and education in quantitative analysis and reproducible research, especially for new investigators. The BCB Core provides infrastructure support by helping with data analysis, the development of bioinformatics tools to manage data, and the development of new statistical and computational biology approaches to analyzing complex data sets. The nature of HIV/AIDS research encompassed by Duke CFAR ranges from small-scale exploratory studies by new investigators to established laboratories that generate massive throughput, highly complex data sets. Across this range, the BCB Core has much to offer. For new investigators, the BCB Core provides mentoring in appropriate experimental design and data analysis, as well as review and feedback of the statistical analysis plan in papers and grant proposals. For investigators and core facilities that generate complex data sets, the BCB Core aids in the development of informatics tools to manage the data, as well we novel statistical methods to better understand the data. The BCB Core also trains laboratory members in practical computing and analysis skills to improve the productivity and reproducibility of their research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI064518-12
Application #
9063518
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
12
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Itell, Hannah L; McGuire, Erin P; Muresan, Petronella et al. (2018) Development and application of a multiplex assay for the simultaneous measurement of antibody responses elicited by common childhood vaccines. Vaccine 36:5600-5608
Wiehe, Kevin; Bradley, Todd; Meyerhoff, R Ryan et al. (2018) Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. Cell Host Microbe 23:759-765.e6
McGuire, Erin P; Fong, Youyi; Toote, Christopher et al. (2018) HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine. J Virol 92:
Skalski, Linda M; Towe, Sheri L; Sikkema, Kathleen J et al. (2018) Memory Impairment in HIV-Infected Individuals with Early and Late Initiation of Regular Marijuana Use. AIDS Behav 22:1596-1605
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Okeke, Nwora Lance; Alenezi, Fawaz; Bloomfield, Gerald S et al. (2018) Determinants of Left Ventricular Hypertrophy and Diastolic Dysfunction in an HIV Clinical Cohort. J Card Fail 24:496-503
Clement, Meredith E; Seidelman, Jessica; Wu, Jiewei et al. (2018) An educational initiative in response to identified PrEP prescribing needs among PCPs in the Southern U.S. AIDS Care 30:650-655
Price, Alexander M; Messinger, Joshua E; Luftig, Micah A (2018) c-Myc Represses Transcription of Epstein-Barr Virus Latent Membrane Protein 1 Early after Primary B Cell Infection. J Virol 92:
Knettel, Brandon A; Cichowitz, Cody; Ngocho, James Samwel et al. (2018) Retention in HIV Care During Pregnancy and the Postpartum Period in the Option B+ Era: Systematic Review and Meta-Analysis of Studies in Africa. J Acquir Immune Defic Syndr 77:427-438

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