? Biostatistics and Computational Biology Core (Core E) The principal mission of the Duke CFAR is to establish, enrich, and provide continued infrastructure support to an academic research environment that will effectively promote collaboration and coordination among the community of HIV/AIDS investigators at Duke. The Biostatistics and Computational Biology (BCB) Core supports this mission by providing quantitative consulting services in support of experimental design, development of manuscripts and improvement of grant proposals. The BCB Core enriches the academic research environment by providing mentoring and education in quantitative analysis and reproducible research, especially for new investigators. The BCB Core provides infrastructure support by helping with data analysis, the development of bioinformatics tools to manage data, and the development of new statistical and computational biology approaches to analyzing complex data sets. The nature of HIV/AIDS research encompassed by Duke CFAR ranges from small-scale exploratory studies by new investigators to established laboratories that generate massive throughput, highly complex data sets. Across this range, the BCB Core has much to offer. For new investigators, the BCB Core provides mentoring in appropriate experimental design and data analysis, as well as review and feedback of the statistical analysis plan in papers and grant proposals. For investigators and core facilities that generate complex data sets, the BCB Core aids in the development of informatics tools to manage the data, as well we novel statistical methods to better understand the data. The BCB Core also trains laboratory members in practical computing and analysis skills to improve the productivity and reproducibility of their research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI064518-12
Application #
9063518
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
12
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Ferrari, Guido (2018) Tandem bispecific broadly neutralizing antibody - a novel approach to HIV-1 treatment. J Clin Invest 128:2189-2191
Dai, Joanne; Luftig, Micah A (2018) Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation. J Immunol 200:1727-1736
Gichane, Margaret W; Sullivan, Kristen A; Shayo, Aisa M et al. (2018) Caregiver role in HIV medication adherence among HIV-infected orphans in Tanzania. AIDS Care 30:701-705
Ramadhani, Habib O; Muiruri, Charles; Maro, Venance P et al. (2018) Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance. AIDS Behav 22:1671-1678
Kelly, Matthew S; Surette, Michael G; Smieja, Marek et al. (2018) Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana. Pediatr Infect Dis J 37:1176-1183
Ramos, Julia V; Mmbaga, Blandina T; Turner, Elizabeth L et al. (2018) Modality of Primary HIV Disclosure and Association with Mental Health, Stigma, and Antiretroviral Therapy Adherence in Tanzanian Youth Living with HIV. AIDS Patient Care STDS 32:31-37
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Sikkema, Kathleen J; Choi, Karmel W; Robertson, Corne et al. (2018) Development of a coping intervention to improve traumatic stress and HIV care engagement among South African women with sexual trauma histories. Eval Program Plann 68:148-156
Watt, Melissa H; Cichowitz, Cody; Kisigo, Godfrey et al. (2018) Predictors of postpartum HIV care engagement for women enrolled in prevention of mother-to-child transmission (PMTCT) programs in Tanzania. AIDS Care :1-12
Itell, Hannah L; McGuire, Erin P; Muresan, Petronella et al. (2018) Development and application of a multiplex assay for the simultaneous measurement of antibody responses elicited by common childhood vaccines. Vaccine 36:5600-5608

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