? Biostatistics and Computational Biology Core (Core E) The principal mission of the Duke CFAR is to establish, enrich, and provide continued infrastructure support to an academic research environment that will effectively promote collaboration and coordination among the community of HIV/AIDS investigators at Duke. The Biostatistics and Computational Biology (BCB) Core supports this mission by providing quantitative consulting services in support of experimental design, development of manuscripts and improvement of grant proposals. The BCB Core enriches the academic research environment by providing mentoring and education in quantitative analysis and reproducible research, especially for new investigators. The BCB Core provides infrastructure support by helping with data analysis, the development of bioinformatics tools to manage data, and the development of new statistical and computational biology approaches to analyzing complex data sets. The nature of HIV/AIDS research encompassed by Duke CFAR ranges from small-scale exploratory studies by new investigators to established laboratories that generate massive throughput, highly complex data sets. Across this range, the BCB Core has much to offer. For new investigators, the BCB Core provides mentoring in appropriate experimental design and data analysis, as well as review and feedback of the statistical analysis plan in papers and grant proposals. For investigators and core facilities that generate complex data sets, the BCB Core aids in the development of informatics tools to manage the data, as well we novel statistical methods to better understand the data. The BCB Core also trains laboratory members in practical computing and analysis skills to improve the productivity and reproducibility of their research.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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Special Emphasis Panel (ZAI1)
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Ferrari, Guido (2018) Tandem bispecific broadly neutralizing antibody - a novel approach to HIV-1 treatment. J Clin Invest 128:2189-2191
Dai, Joanne; Luftig, Micah A (2018) Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation. J Immunol 200:1727-1736
Gichane, Margaret W; Sullivan, Kristen A; Shayo, Aisa M et al. (2018) Caregiver role in HIV medication adherence among HIV-infected orphans in Tanzania. AIDS Care 30:701-705
Ramadhani, Habib O; Muiruri, Charles; Maro, Venance P et al. (2018) Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance. AIDS Behav 22:1671-1678
Kelly, Matthew S; Surette, Michael G; Smieja, Marek et al. (2018) Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana. Pediatr Infect Dis J 37:1176-1183
Ramos, Julia V; Mmbaga, Blandina T; Turner, Elizabeth L et al. (2018) Modality of Primary HIV Disclosure and Association with Mental Health, Stigma, and Antiretroviral Therapy Adherence in Tanzanian Youth Living with HIV. AIDS Patient Care STDS 32:31-37
Saunders, Kevin O; Santra, Sampa; Parks, Robert et al. (2018) Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates. J Virol 92:
Sikkema, Kathleen J; Choi, Karmel W; Robertson, Corne et al. (2018) Development of a coping intervention to improve traumatic stress and HIV care engagement among South African women with sexual trauma histories. Eval Program Plann 68:148-156
Watt, Melissa H; Cichowitz, Cody; Kisigo, Godfrey et al. (2018) Predictors of postpartum HIV care engagement for women enrolled in prevention of mother-to-child transmission (PMTCT) programs in Tanzania. AIDS Care :1-12
Itell, Hannah L; McGuire, Erin P; Muresan, Petronella et al. (2018) Development and application of a multiplex assay for the simultaneous measurement of antibody responses elicited by common childhood vaccines. Vaccine 36:5600-5608

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