Abstract

The Developmental Core (Core B) will support and develop the next-generation of HIV/AIDS researchers at the UR. The Core will administer the CFAR's pilot grant program, conduct mentoring and career development of young investigators, and provide seminars and scientific symposia that create an outstanding scientific and intellectual environment for HIV/AIDS research at the UR. The Core will use its pilot program to support young faculty and to also promote overall CFAR objectives, including the establishment of new multidisciplinary collaborations and the promotion of innovative studies that support the mission of the CFAR's Scientific Working Groups (SWGs) and leverage unique institutional assets. During our funding cycle as a Developmental CFAR (D-CFAR), this Core has funded 26 pilot awards in an aggregate amount of $641,606, which have yielded a 10:1 return on investment in terms of new grant awards. Its pilot and mentoring programs have also had a profound impact on the career development of young HIV/AIDS researchers. This has included 2 KL2 awards from the UR CTSI;2 awards from the national Creative New Ideas in HIV Research (CNIHR) program (out of only 22 total awards made between 2010 and 2012);4 CFAR supplement awards in 2011 (including 1 of only 2 nanotech supplements awarded nationally);and the academic promotion of 6 young faculty members.
Three Aims are proposed.
Aim 1 will stimulate new research on HIV/AIDS by funding pilot awards targeted to: young faculty members;innovative studies with potential for high impact;and multidisciplinary collaborations that span different departments and schools, including projects that leverage unique institutional assets.
Aim 2 will provide comprehensive, structured mentoring support for the early career development of young faculty, and a grant pre-review service intended to enhance the quality of extramural grant applications from new investigators. Finally, Aim 3 will create an outstanding intellectual and scientific environment for HIV/AIDS researchers, by supporting seminars, symposia, and a range of training courses and workshops.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI078498-06
Application #
8520712
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Project Start
2008-05-01
Project End
2018-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
6
Fiscal Year
2013
Total Cost
$352,800
Indirect Cost
$99,679

  Institution

Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Rice, John D; Strawderman, Robert L; Johnson, Brent A (2018) Regularity of a renewal process estimated from binary data. Biometrics 74:566-574
Nogales, Aitor; Piepenbrink, Michael S; Wang, Jiong et al. (2018) A Highly Potent and Broadly Neutralizing H1 Influenza-Specific Human Monoclonal Antibody. Sci Rep 8:4374
Zhou, Tian; Su, Hang; Dash, Prasanta et al. (2018) Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials 151:53-65
Horita, Yasuhiro; Alsultan, Abdullah; Kwara, Awewura et al. (2018) Evaluation of the Adequacy of WHO Revised Dosages of the First-Line Antituberculosis Drugs in Children with Tuberculosis Using Population Pharmacokinetic Modeling and Simulations. Antimicrob Agents Chemother 62:
Yang, Hongmei; Holden-Wiltse, Jeanne; Topham, David J et al. (2018) Maximum Likelihood Estimation of Titer via a Power Family of Four-Parameter Logistic Model. J Biopharm Stat 28:492-500
Belashov, Ivan A; Crawford, David W; Cavender, Chapin E et al. (2018) Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription. Nucleic Acids Res 46:6401-6415
McMillan, JoEllyn; Szlachetka, Adam; Zhou, Tian et al. (2018) Pharmacokinetic testing of a first generation cabotegravir prodrug in rhesus macaques. AIDS :
Hammond, Jennetta W; Qiu, Wen Q; Marker, Daniel F et al. (2018) HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q. Glia 66:2563-2574
Dompreh, Albert; Tang, Xiaoli; Zhou, Jianlin et al. (2018) Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis. Antimicrob Agents Chemother 62:
Leblanc, Natalie M; Mitchell, Jason (2018) Providers' Perceptions of Couples' HIV Testing and Counseling (CHTC): Perspectives From a U.S. HIV Epicenter. Couple Family Psychol 7:22-33

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