HIGHLY IMPACTED POPULATIONS SCIENTIFIC WORKING GROUP (SWG1) Project Summary The Specific Aims of the Highly Impacted Populations (HIP) Scientific Working Group (SWG) are to: 1) generate innovative HIV/AIDS research to promote prevention, care and treatment among highly impacted populations in the Washington, DC area, including MSM, gender and sexual minorities, criminal justice affected communities and vulnerable women; 2) collect data and conduct analyses that highlight the multi-level factors (e.g., social structural, community, behavioral, biomedical) affecting risk, care and treatment outcomes in each of these highly impacted populations and identify and explore the implications of overlap among them and critical cross-cutting theories, concepts and approaches (e.g., stigma, legality and policing, displacement and disruption) that affect some or all of them; and 3) create new opportunities for early stage investigators, engage established investigators who are new to HIV/AIDS research and continue to build on the work of currently R01-funded investigators in generating research among these highly impacted populations. Emphasis on these highly impacted populations is consistent with the DC CFAR's aim to address the DC epidemic, which is concentrated among MSM and sexual minorities (particularly of color) and where women of color are much more likely than their white counterparts to be HIV-infected. It is also consistent with the DC CFAR commitment to better understanding disparities in HIV/AIDS and, especially with its emphasis on criminal justice affected populations, the social structural dimensions of these disparities.
The aims of the HIP SWG will be accomplished through a combination of activities including: monthly meetings of SWG subgroups addressing distinct issues related to these highly impacted populations; quarterly meetings of the full SWG to discuss and generate new research related to overlapping issues and themes across these populations; proactive review of program announcements and requests for proposals and convening of groups of potential collaborators to respond, as relevant; co- sponsorship with CFAR Cores of seminars, talks and workshops on SWG-related themes; and collaboration with the Developmental Core in soliciting pilot projects on SWG-related topics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
1P30AI117970-01
Application #
8897788
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2015-06-01
Budget End
2016-05-31
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost
Name
George Washington University
Department
Type
DUNS #
043990498
City
Washington
State
DC
Country
United States
Zip Code
20052
Desrosiers, Aimee; Levy, Matthew; Dright, Aurnell et al. (2018) A Randomized Controlled Pilot Study of a Culturally-Tailored Counseling Intervention to Increase Uptake of HIV Pre-exposure Prophylaxis Among Young Black Men Who Have Sex with Men in Washington, DC. AIDS Behav :
Ghosh, Mimi; Daniels, Jason; Pyra, Maria et al. (2018) Impact of chronic sexual abuse and depression on inflammation and wound healing in the female reproductive tract of HIV-uninfected and HIV-infected women. PLoS One 13:e0198412
Houzet, Laurent; PĂ©rez-Losada, Marcos; Matusali, Giulia et al. (2018) Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques Is Dominated by Virus Originating from Multiple Genital Organs. J Virol 92:
Macedo, Amanda B; Novis, Camille L; De Assis, Caroline M et al. (2018) Dual TLR2 and TLR7 agonists as HIV latency-reversing agents. JCI Insight 3:
Ren, Yanqin; Korom, Maria; Truong, Ronald et al. (2018) Susceptibility to Neutralization by Broadly Neutralizing Antibodies Generally Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs. J Virol 92:
Orekhov, Alexander N; Pushkarsky, Tatiana; Oishi, Yumiko et al. (2018) HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages. Exp Mol Pathol 105:202-207
Huang, Szu-Han; Ren, Yanqin; Thomas, Allison S et al. (2018) Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells. J Clin Invest 128:876-889
Adzhubei, Alexei A; Anashkina, Anastasia A; Tkachev, Yaroslav V et al. (2018) Modelling interaction between HIV-1 Nef and calnexin. AIDS 32:2103-2111
Clutton, Genevieve Tyndale; Jones, R Brad (2018) Diverse Impacts of HIV Latency-Reversing Agents on CD8+ T-Cell Function: Implications for HIV Cure. Front Immunol 9:1452
Ghosh, Mimi; Jais, Mariel; Biswas, Roshni et al. (2018) Immune biomarkers and anti-HIV activity in the reproductive tract of sexually active and sexually inactive adolescent girls. Am J Reprod Immunol 79:e12846

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