The HIV Eradication Scientific Working Group (SWG) was created to directly address one of the high priority research areas of the OAR: ?to develop novel approaches and strategies to eliminate viral reservoirs that could lead toward a cure or lifelong remission of HIV infection?. Despite the major success of combination antiretroviral therapy (cART) in suppressing viral replication and preventing disease progression, HIV-1 infection persists in a latent reservoir, composed primarily of a long-lived population of resting memory CD4+ T cells. These latently infected cells harbor replication competent HIV-1 DNA, therefore the elimination of the latent viral reservoir is essential to eradicating HIV-1 infection. Major challenges to the elimination of the reservoir are the lack of: (i) robust, sensitive and reliable assays to accurately measure and localize the reservoir of replication-competent proviruses; (ii) basic understanding of the mechanisms that lead to latent reservoirs; and (iii) reliable methods to reactivate latent cells and to target them for killing. The HIV Eradication SWG was formed to bring together outstanding investigators who have not previously collaborated: (i) from within the three ERC-CFAR institutions; (ii) from other New York City institutions, including Columbia University Medical Center, New York University, and Icahn School of Medicine at Mount Sinai; and (iii) non-AIDS experts from other fields, to develop a multi-pronged approach to synergize basic, translational, and clinical efforts targeted towards HIV eradication. This SWG will leverage the clinical samples, assays and technologies available through the laboratory and clinical cores of the ERC-CFAR to drive research efforts to eradicate HIV-1 infection and thereby prevent new infections. This SWG aims to: (i) foster collaborations among SWG members and affiliates to focus on the molecular mechanisms of latency and on the development and evaluation of novel and alternate modalities for HIV Cure; (ii) use the ERC-CFAR cores to support and recruit experts from non-HIV/AIDS areas and Early Stage Investigators to develop innovative technologies to quantify and eradicate HIV infection; and (iii) To obtain funding for research projects that are developed through new collaborations and ideas formed in the SWG to increase our understanding of the underlying mechanisms that generate and maintain latent reservoirs and to develop reliable methods to reactivate latent cells and to target them for killing.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI124414-05
Application #
9922255
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
081266487
City
Bronx
State
NY
Country
United States
Zip Code
10461
Patel, Viraj V; Ginsburg, Zoƫ; Golub, Sarit A et al. (2018) Empowering With PrEP (E-PrEP), a Peer-Led Social Media-Based Intervention to Facilitate HIV Preexposure Prophylaxis Adoption Among Young Black and Latinx Gay and Bisexual Men: Protocol for a Cluster Randomized Controlled Trial. JMIR Res Protoc 7:e11375
Marhefka, Stephanie L; Turner, DeAnne; Lockhart, Elizabeth et al. (2018) Meeting Our Patients ""Where They Are"": Video-Group Smoking Cessation for People Living With HIV. J Assoc Nurses AIDS Care 29:338-344
Ross, Jonathan; Cunningham, Chinazo O; Hanna, David B (2018) HIV outcomes among migrants from low-income and middle-income countries living in high-income countries: a review of recent evidence. Curr Opin Infect Dis 31:25-32
George, Gavin; Chetty, Taruna; Strauss, Michael et al. (2018) Costing analysis of an SMS-based intervention to promote HIV self-testing amongst truckers and sex workers in Kenya. PLoS One 13:e0197305
Mendoza, Pilar; Gruell, Henning; Nogueira, Lilian et al. (2018) Combination therapy with anti-HIV-1 antibodies maintains viral suppression. Nature 561:479-484
Veenstra, Mike; Byrd, Desiree A; Inglese, Matilde et al. (2018) CCR2 on Peripheral Blood CD14+CD16+ Monocytes Correlates with Neuronal Damage, HIV-Associated Neurocognitive Disorders, and Peripheral HIV DNA: reseeding of CNS reservoirs? J Neuroimmune Pharmacol :
Cossarini, Francesca; Hanna, David B; Ginsberg, Mindy S et al. (2018) Missed Opportunities for HIV Prevention: Individuals Who HIV Seroconverted Despite Accessing Healthcare. AIDS Behav 22:3519-3524
Hill, Bianca S; Patel, Viraj V; Haughton, Lorlette J et al. (2018) Leveraging Social Media to Explore Black Women's Perspectives on HIV Pre-exposure Prophylaxis. J Assoc Nurses AIDS Care 29:107-114
Bhalakia, Avni M; Talib, Hina J; Choi, Jaeun et al. (2018) Acceptance of Routine HIV Testing by Hospitalized Adolescents and Young Adults. Hosp Pediatr 8:187-193
Hannaford, Alisse; Lipshie-Williams, Madeleine; Starrels, Joanna L et al. (2018) The Use of Online Posts to Identify Barriers to and Facilitators of HIV Pre-exposure Prophylaxis (PrEP) Among Men Who Have Sex with Men: A Comparison to a Systematic Review of the Peer-Reviewed Literature. AIDS Behav 22:1080-1095

Showing the most recent 10 out of 27 publications