The purpose of this Center is to provide a multidisciplinary approach to hormone action. The research theme is the cellular and subcellular mechanism of action of insulin and insulin-like growth factors, but we also study the mechanisms of action of steroid hormones and cyclic nucleotides, giving a comprehensive approach to hormone action. The Center consists of several components. Resources include five Cores: Administrative Services; Computer Services; Cell Biology (Media and Cell Production and Monoclonal Antibody Production); Membrane Biology (Central Facility for Peptide Iodination, Membrane Preparation and Analysis and Receptor Localization); and Molecular Biology (Recombinant DNA and DNA synthesis). These will be supplemented by an Enrichment Program (seminar speakers and topical workshops) and a Pilot and Feasibility Program (supports pilot studies related to the Center theme). This Center will benefit our work in the following ways: (1) The multidisciplinary approach will afford us the talent and techniques required for the contemporary approach to hormone action; (2) the Enrichment Program and the communication through the Core facilities will lead to collaboration and hence increased productivity; (3) the Core resources will provide services not currently available and will allow us to centralize many duplicated functions; and (4) the Center will allow us, through the pilot studies, to test new ideas in insulin action and to attact new investigators into this field.
Showing the most recent 10 out of 105 publications
