The Translational Research Core is designed to promote and facilitate human subject research in skinbiology and skin disease.
The first aim i s to provide a cost-efficient, central resource to identify and recruitvolunteers to participate in human in vivo studies and/or donate blood or skin biopsy tissue for ex vivo/in vitroinvestigations. The Core performs procedures such as skin exposure to simulated solar radiation, haptensensitization & elicitation, non-invasive monitoring (e.g., ultrasonography, chromometry, transepidermalwater loss measurement) and tissue acquisition (venipuncture, punch & keratome biopsies). The utilizationof these functions are expanded mainly by active interactions with physicians who refer patients and withother investigators through the Case Comprehensive Cancer Center, the General Clinical Research Center,Center for Aids Research, and other research foci within the University. A research assistant coordinatesthese services.
The second aim i s to provide overall management of clinical trials of novel therapies broughtfrom the laboratory to the bedside with emphasis on providing optimal translational and clinical data. Agroup with expertise in general trial design as well as data and safety monitoring are assembled to efficientlydirect or conduct high quality studies that arise through interaction with various investigators interested inskin research. Additionally, interactions between clinical and laboratory researchers are fostered to insertadjunctive laboratory studies to clarify mechanisms of action of therapies and pathomechanisms of disease.
The third aim i s to foster career development of young investigators and junior faculty in the area of humansubject-based skin research. This involves providing support at multiple levels (e.g. IRB submission, protocoldesign, data analysis, manuscript preparation) depending on investigator needs.
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