Translational Research Core Facility is specifically designed to promote and facilitate involvement of human subjects for skin and skin disease-related research.
It aims to derive maximum information from human studies by providing a resource that integrates organization of patient cohorts with mechanistic studies using tissues, outcomes research, clinical trials, and laboratory investigation. This Core is structured to meet the SDRC membership's needs for human tissue, (e.g. punch biopsies, keratomes, suction blisters), to provide the SDRC membership with enabling technologies for human skin investigation (e.g. simulated solar radiation, chromometer, transepidermal water loss device), and to lead in the development of novel technologies that will benefit SDRC membership (e.g. imaging system for photodynamic therapy, skin ultrasound, in vivo confocal imaging).
It aims to provide a cost-efficient, central resource to identify and recruit volunteers to participate in human in vivo studies and/or donate blood or skin biopsy tissue for ex vivo/in vitro investigations. The utilization of core functions is expanded mainly by active interactions with physicians who refer patients and with other investigators through the Clinical and Translational Science Collaborative, Case Comprehensive Cancer Center, Center for Aids Research, and other research foci within the University. A research assistant coordinates these services. The core also aims to provide overall management of clinical trials of novel therapies brought from the laboratory to the bedside with emphasis on providing optimal translational and clinical data. A group with expertise in general trial design, regulatory and compliance aspects of human studies, assemble to efficiently direct or conduct high quality studies that arise through interaction with various investigators interested in skin research. Additionally, interactions between clinical and laboratory researchers are fostered to insert adjunctive laboratory studies to clarify mechanisms of action of therapies and pathomechanisms of disease. The core also provides support, mentoring and education regarding human research compliance, to members of the SDRC.

Public Health Relevance

TRC is a critical link for skin diseases related research, because at some point, almost every investigator needs to validate their findings in skin disease. Furthermore, the TRC is critical to the developmental therapeutics components of the SDRC.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-HL)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Case Western Reserve University
United States
Zip Code
Das, Lopa M; Binko, Amy M; Traylor, Zachary P et al. (2018) Defining the timing of 25(OH)D rescue following nitrogen mustard exposure. Cutan Ocul Toxicol 37:127-132
Griffith, Alexis D; Zaidi, Asifa K; Pietro, Ashley et al. (2018) A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice. Sci Rep 8:14451
Zaidi, Asifa K; Spaunhurst, Katrina; Sprockett, Daniel et al. (2018) Characterization of the facial microbiome in twins discordant for rosacea. Exp Dermatol 27:295-298
Bhaskaran, Natarajan; Liu, Zhihui; Saravanamuthu, Senthil S et al. (2018) Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity. Front Immunol 9:184
Mukherjee, Pranab K; Chandra, Jyotsna; Retuerto, Mauricio et al. (2018) Effect of alcohol-based hand rub on hand microbiome and hand skin health in hospitalized adult stem cell transplant patients: A pilot study. J Am Acad Dermatol 78:1218-1221.e5
Soler, David C; Young, Andrew E; Griffith, Alexis D et al. (2017) Overexpression of AQP3 and AQP10 in the skin exacerbates psoriasiform acanthosis. Exp Dermatol 26:949-951
Wang, QuanQiu; McCormick, Thomas S; Ward, Nicole L et al. (2017) Combining mechanism-based prediction with patient-based profiling for psoriasis metabolomics biomarker discovery. AMIA Annu Symp Proc 2017:1734-1743
Fritz, Yi; Klenotic, Philip A; Swindell, William R et al. (2017) Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice. J Invest Dermatol 137:696-705
Scott, Jeffrey F; Das, Lopa M; Ahsanuddin, Sayeeda et al. (2017) Oral Vitamin D Rapidly Attenuates Inflammation from Sunburn: An Interventional Study. J Invest Dermatol 137:2078-2086
Monin, Leticia; Gudjonsson, Johann E; Childs, Erin E et al. (2017) MCPIP1/Regnase-1 Restricts IL-17A- and IL-17C-Dependent Skin Inflammation. J Immunol 198:767-775

Showing the most recent 10 out of 403 publications