Abstract

Cell-cell interactions play an important role in cell fate decision and pattern formation in the development of multicellular organisms. One of the evolutionarily conserved pathways that plays a central role in local cell interactions is the Notch signal transduction pathway. Initially discovered by developmental biologists working on invertebrates such as Drosophila and C. elegans, the Notch pathway has recently been found to control various developmental processes in mammals. However, the role of Notch signaling in epidermal development, especially its role in epidermal stem cell differentiation, has not been studied. Here I propose to investigate the role of Notch signaling during epidermal development. Specifically I propose to use transgenic mouse technique to hyperactivate or block Notch pathway in the epidermis and to examine their effects on epidermal development. will also develop a sensitive assay to follow the in situ pattern of Notch activation in the developing epidermis. This assay can be generally applied to examine the temporal and spatial pattern of Notch signaling in any developing tissue.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR041940-08
Application #
6100568
Study Section
Project Start
1999-06-01
Project End
2000-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Acharya, Asha; Baek, Seung Tae; Banfi, Serena et al. (2011) Efficient inducible Cre-mediated recombination in Tcf21 cell lineages in the heart and kidney. Genesis 49:870-7
Straud, Sarah; Zubovych, Iryna; De Brabander, Jef K et al. (2010) Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. PLoS One 5:e11629
Chapman, Shelby L; Sicot, F-X; Davis, Elaine C et al. (2010) Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury. Arterioscler Thromb Vasc Biol 30:68-74
Yanagisawa, Hiromi; Davis, Elaine C (2010) Unraveling the mechanism of elastic fiber assembly: The roles of short fibulins. Int J Biochem Cell Biol 42:1084-93
Choi, Jiwon; Bergdahl, Andreas; Zheng, Qian et al. (2009) Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly. Matrix Biol 28:211-20
Jaeckle Santos, Lane J; Xing, Chao; Barnes, Robert B et al. (2008) Refined mapping of X-linked reticulate pigmentary disorder and sequencing of candidate genes. Hum Genet 123:469-76
Takayama, Yoshiharu; May, Petra; Anderson, Richard G W et al. (2005) Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta). J Biol Chem 280:18504-10
Wang, Huixia; He, Xuming; Band, Mark et al. (2005) A study of inter-lab and inter-platform agreement of DNA microarray data. BMC Genomics 6:71
Sinha, Suwan K; Zachariah, Sunny; Quinones, Herson I et al. (2002) Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor. J Biol Chem 277:44953-61
Sellati, T J; Waldrop, S L; Salazar, J C et al. (2001) The cutaneous response in humans to Treponema pallidum lipoprotein analogues involves cellular elements of both innate and adaptive immunity. J Immunol 166:4131-40

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