The primary objective of the Morphology Core is to enhance the versatility and productivity for both novicecutaneous investigators (P & F funded scientists) and established skin investigators by facilitating access totechniques directed toward the microscopic analysis of skin samples. We will continue to accomplish these goalsby serving as a repository of successful/unsuccessful immunohistochemical staining protocols with proven skinspecificantisera, by providing screening and optimization of new antisera for immunohistochemical staining,and by assisting investigators with interpretation as they seek to define skin abnormalities and responses. Toachieve these objectives, the Core will render state-of-the-art embedding, sectioning (frozens or paraffins), andstaining (primarily immunohistochemical staining) in a timely and low-cost basis by trained experts. TheDirector and Core personnel will supply teaching assistance and advice in microscopic techniques useful for skinanalysis for a wide range of individuals including P & F investigators, funded SDRCC investigators, and their postdoctoralfellows, graduate, students, and laboratory personnel. The Morphology Core will continue to provide apioneering/nurturing environment where cutting edge immunohistochemical techniques are initially tried andachieved under the guidance of an experienced team. The Core will also continue to introduce of new reagentsand technological advancements that exhibit greater sensitivities. We will continue to generate workingprotocols with pathway specific immunoprobes. The Core will work closely to help investigators customizepanels of standardized immunomarkers suitable for use in tissue microarrays. Cooperative interactions amongthe other SDRCC Cores will occur with ease. Since this Core is a portion of Vanderbilt's Institutional Core system,liaisons are well established with other relevant Cores such as the Human Tissue and Pathology SharedResource, Molecular Recognition (Antisera Production) Core, Small Animal Imaging Core, the ElectronMicroscopy Core, Proteomics Core or Cell Imaging/Confocal Core.
| Russell, Shirley B; Smith, Joan C; Huang, Minjun et al. (2015) Pleiotropic Effects of Immune Responses Explain Variation in the Prevalence of Fibroproliferative Diseases. PLoS Genet 11:e1005568 |
| Velez Edwards, Digna R; Tsosie, Krystal S; Williams, Scott M et al. (2014) Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans. Hum Genet 133:1513-23 |
| Duncan, F Jason; Silva, Kathleen A; Johnson, Charles J et al. (2013) Endogenous retinoids in the pathogenesis of alopecia areata. J Invest Dermatol 133:334-43 |
| Takahashi, Keiko; Mernaugh, Raymond L; Friedman, David B et al. (2012) Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase. Proc Natl Acad Sci U S A 109:1985-90 |
| Jandova, Jana; Eshaghian, Alex; Shi, Mingjian et al. (2012) Identification of an mtDNA mutation hot spot in UV-induced mouse skin tumors producing altered cellular biochemistry. J Invest Dermatol 132:421-8 |
| Jandova, Jana; Shi, Mingjian; Norman, Kimberly G et al. (2012) Somatic alterations in mitochondrial DNA produce changes in cell growth and metabolism supporting a tumorigenic phenotype. Biochim Biophys Acta 1822:293-300 |
| Sundberg, J P; Taylor, D; Lorch, G et al. (2011) Primary follicular dystrophy with scarring dermatitis in C57BL/6 mouse substrains resembles central centrifugal cicatricial alopecia in humans. Vet Pathol 48:513-24 |
| Harries, M J; Sun, J; Paus, R et al. (2010) Management of alopecia areata. BMJ 341:c3671 |
| Yang, Jinming; Splittgerber, Ryan; Yull, Fiona E et al. (2010) Conditional ablation of Ikkb inhibits melanoma tumor development in mice. J Clin Invest 120:2563-74 |
| Russell, Shirley B; Russell, James D; Trupin, Kathryn M et al. (2010) Epigenetically altered wound healing in keloid fibroblasts. J Invest Dermatol 130:2489-96 |
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