Abstract

The primary focus of the Animal Resource Core will be to facilitate the use of the murine model of autoimmune arthritis for the study of autoimmunity and inflammatory responses in the rheumatic diseases. We will 1) emphasize both the training and education of RDRCC investigators, young investigators, and established investigators new to-the rheumatic diseases in the utilization of this model; 2) introduce modern approaches to multi-color immunofluorescence and flow cytometric analysis of the cells involved in autoimmune and inflammatory responses; and 3) assist investigators with the breeding, backcrossing to CIA susceptible strains, and screening of genetically altered strains of mice. The centralization of these functions within this core will greatly facilitate the RDRC investigator's studies of rheumatic disease processes through the establishment of consistent and reproducible, quality controlled procedures and reagents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR047379-02
Application #
6663358
Study Section
Special Emphasis Panel (ZAR1)
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Tennessee Health Science Center
Department
Type
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163

  Publications

Hasty, Karen A; Cho, Hongsik (2016) Stem Cell Considerations for the Clinician. Phys Med Rehabil Clin N Am 27:855-870
Qian, Zhaohui; Latham, Kary A; Whittington, Karen B et al. (2013) Engineered regulatory T cells coexpressing MHC class II:peptide complexes are efficient inhibitors of autoimmune T cell function and prevent the development of autoimmune arthritis. J Immunol 190:5382-91
Qian, Zhaohui; Latham, Kary A; Whittington, Karen B et al. (2010) An autoantigen-specific, highly restricted T cell repertoire infiltrates the arthritic joints of mice in an HLA-DR1 humanized mouse model of autoimmune arthritis. J Immunol 185:110-8
Xing, Zhiqing; Schwab, Luciana P; Alley, Carie F et al. (2008) Titanium particles that have undergone phagocytosis by macrophages lose the ability to activate other macrophages. J Biomed Mater Res B Appl Biomater 85:37-41
Ye, Zhaoyang; Houssein, Houssam S Hajj; Mahato, Ram I (2007) Bioconjugation of oligonucleotides for treating liver fibrosis. Oligonucleotides 17:349-404
Xing, Zhiqing; Hasty, Karen A; Smith, Richard A (2007) Administration of pamidronate alters bone-titanium attachment in the presence of endotoxin-coated polyethylene particles. J Biomed Mater Res B Appl Biomater 83:354-8
Yi, Ae-Kyung; Yoon, Hyunsook; Park, Jeoung-Eun et al. (2006) CpG DNA-mediated induction of acute liver injury in D-galactosamine-sensitized mice: the mitochondrial apoptotic pathway-dependent death of hepatocytes. J Biol Chem 281:15001-12
Rosloniec, Edward F; Brandstetter, Tilmann; Leyer, Sigmar et al. (2006) Second-generation peptidomimetic inhibitors of antigen presentation effectively treat autoimmune diseases in HLA-DR-transgenic mouse models. J Autoimmun 27:182-95
Carbone, L D; Warrington, K J; Barrow, K D et al. (2006) Pamidronate infusion in patients with systemic sclerosis results in changes in blood mononuclear cell cytokine profiles. Clin Exp Immunol 146:371-80
Rosloniec, Edward F; Ivey 3rd, Robert A; Whittington, Karen B et al. (2006) Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen. J Immunol 177:3884-92

Showing the most recent 10 out of 24 publications