The University of Michigan proposes to renew funding for its Rheumatic Diseases Research Core Center (UM-RDCC). The UM-RDCC is a broadly based effort involving approximately eighty faculty, who seek to apply a broad range of research skills, backgrounds, and approaches to investigation of fundamental issues in the etiology and pathogenesis of rheumatic diseases and in development of a scientific basis for novel therapeutics. The UM-RDCC will foster collaborations between investigators in thematic areas of research strength and interest, such as development and testing of innovative therapeutics, analysis of immune mechanisms in rheumatic diseases and investigation of organ-targeted inflammatory and tissue remodeling pathways. The UM-RDCC will also foster disease focused laboratory and translational research linked to clinical research programs. Activities in the Center will be supported by six Biomedical Core Facilities, including Flow Cytometry, Hybridoma, Vector, Transgenic Animal, Protein Structure, and Microarray. Three Pilot and Feasibility Projects are proposed, two of which are led by new faculty recently recruited to the UMRDCC, whose focus is the pathogenesis of inflammatory arthritis. The third Pilot and Feasibility Project is led by an experienced dermatology investigator who will mechanistically investigate a highly innovative approach to treating scleroderma. The UM-RDCC and its administrative unit will be directed by David A. Fox, M.D., who has fifteen years of experience in administration of broadly based, NIAMS-funded center programs. Rory Marks, M.D., Associate Professor of Rheumatology is proposed to continue as the UMRDCC Associate Director, with special responsibilities for supervision of the biomedical cores. The Center's administrative team will be assisted by an Executive Committee, an Internal Advisory Committee, and two External Scientific Advisors, Drs. Michael Brenner and Michael Holers. The UM-RDCC is constructed to maximally engage the talents and resources of the University of Michigan to focus on research in the rheumatic diseases. The Center leadership will maintain close links between the basic and pre-clinical research activities of the UM-RDCC and expanding clinical investigation in the rheumatic diseases at the University of Michigan, so as to maximize the impact of UM-RDCC discoveries on the health of patients with rheumatic diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
2P30AR048310-06
Application #
7071005
Study Section
Special Emphasis Panel (ZAR1-EHB-D (O1))
Program Officer
Serrate-Sztein, Susana
Project Start
2001-09-28
Project End
2011-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
6
Fiscal Year
2006
Total Cost
$608,000
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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