The capabilities assembled in the SNP Confirmation and High Throughput GenotypingCore (SNP-Gen Core) provide the Center Investigators (and larger institution) a single pointof entry, comprehensive advice (mentoring) for the technical aspects of experimentsmanipulating nucleic acids, access to highly-trained technical personnel and verysophisticated and expensive equipment. For most, the Core will offer assay development,data collection, or nucleotide synthesis. In some situations advice and education will beobtained. This Core centralizes the equipment and experience needed to efficiently andreliably produce high quality nucleic acid analysis data. The services available through thisCore include DMA sequencing, single nucleotide polymorphism (SNP) genotyping,insertion/deletion analysis, tandem repeat genotyping, expression arrays in mouse andman, and SNP arrays. Appropriate internal quality control checks and balances are in placeand are outlined in the revised application. The interaction with each of the CenterInvestigators will be tailored so that the individual training needs of each are met. The coreserves to provide data and services efficiently and economically. In some situationsmassive high throughput data will be generated.
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