Abstract

This project is a collaborative effort involving investigators from the Departments of Biomedical Engineering and Orthopaedic Surgery at Washington University in St. Louis. The main goal of this project is to develop and validate electrospun nanofibers as a new platform for musculoskeletal research, with an initial focus on the demonstration of scaffolds for tissue repairing at the tendon-to-bone insertion site. In this project, we will fabricate nanofibers by electrospinning and then optimize their use as scaffolds for tissue engineering by in vitro cell culture studies. We will then evaluate the performance of these nanofibrous scaffolds in vivo using a clinical-relevant animal model for the repair of supraspinatus tendon at the insertion site.

Public Health Relevance

Our research will work to develop and validate electrospun nanofibers as a new platform for musculoskeletal research, with initial proof of concept application in repair of rotator cuff tendon (shoulder). Potential future applications include orthopaedic repair of skeletal defects related to fractures and bone tumors, and cartilage defects due to injury and osteoarthritis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
1P30AR057235-01
Application #
7680843
Study Section
Special Emphasis Panel (ZAR1-CHW-G (M1))
Project Start
2009-05-11
Project End
2010-03-31
Budget Start
2009-05-11
Budget End
2010-03-31
Support Year
1
Fiscal Year
2009
Total Cost
$75,607
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Rohatgi, Nidhi; Zou, Wei; Collins, Patrick L et al. (2018) ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1. Blood Adv 2:2467-2477
Brophy, R H; Zhang, B; Cai, L et al. (2018) Transcriptome comparison of meniscus from patients with and without osteoarthritis. Osteoarthritis Cartilage 26:422-432
Sun, David; Brodt, Michael D; Zannit, Heather M et al. (2018) Evaluation of loading parameters for murine axial tibial loading: Stimulating cortical bone formation while reducing loading duration. J Orthop Res 36:682-691
Turecamo, S E; Walji, T A; Broekelmann, T J et al. (2018) Contribution of metabolic disease to bone fragility in MAGP1-deficient mice. Matrix Biol 67:1-14
Meyer, Gretchen A (2018) Evidence of induced muscle regeneration persists for years in the mouse. Muscle Nerve 58:858-862
Wang, Chun; Hockerman, Susan; Jacobsen, E Jon et al. (2018) Selective inhibition of the p38? MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals. J Exp Med 215:1315-1325
Chinzei, N; Brophy, R H; Duan, X et al. (2018) Molecular influence of anterior cruciate ligament tear remnants on chondrocytes: a biologic connection between injury and osteoarthritis. Osteoarthritis Cartilage 26:588-599
Rai, Muhammad Farooq; Tycksen, Eric D; Sandell, Linda J et al. (2018) Advantages of RNA-seq compared to RNA microarrays for transcriptome profiling of anterior cruciate ligament tears. J Orthop Res 36:484-497
Chinzei, Nobuaki; Rai, Muhammad Farooq; Hashimoto, Shingo et al. (2018) Evidence for Genetic Contribution to Variation in Post-Traumatic Osteoarthritis in Mice. Arthritis Rheumatol :
Rai, Muhammad Farooq; Pham, Christine Tn (2018) Intra-articular drug delivery systems for joint diseases. Curr Opin Pharmacol 40:67-73

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